To analyze the difference of laparoscopic and open resection for colorectal cancer on pain response and levels of cellular immunity.

A retrospective analysis was performed in 60 patients with colorectal cancer from June 2014 to December 2016. The laparoscopic group (32 cases) received laparoscopic resection of colorectal cancer, and the lopen group (28 cases) received traditional laparotomy of colorectal cancer. Perioperative indicators and levels of T lymphocyte were expressed as mean ±standard deviation and were examined by using t test. Postoperative complications were analyzed by Chi-square test. A P value< 0.05 was considered as statistically significant difference.

The blood loss, postoperative drainage time, feeding time and hospital time of laparoscopic group were less (shorter) than open group (P<0.05). There was no significant difference in VAS before operation (P>0.05), but there was significant difference in VAS after operation(P<0.05), the VAS of laparoscopic group was less than open group. In preoperative time, the levels of CD3⁺ 、CD4⁺ 、CD8⁺ had no significant difference (P>0.05) between the two groups. The levels of CD3⁺ 、CD4⁺ of laparoscopic group were significantly higher than the open group after surgery (P<0.05). The incidence of complications was 6.25% (2/32) in laparoscopic group and was 32.14% (9/28) in open group, with significant difference (P<0.05).

Laparoscopic radical resection of colorectal cancer in patients with has small trauma and low risk of complications, which can effectively alleviate pain symptoms and immune response of patients. It is conducive to postoperative recovery, so it is worthy to clinical application.