To investigate the clinical efficacy and impacts on inflammatory reaction of laparoscopic and open cholecystectomy in treatment of acute calculous cholecystitis.

Clinical data of 117 patients with acute calculous cholecystitis from January 2015 to June 2017 were analyzed retrospectively. In these patients, 61 patients were allocated in the laparoscopic group and 56 patients in the open group. Statistical analysis was performed by using SPSS17.0 software. Perioperative measurement data and score of visual analogue scale (VAS) and inflammatory reaction related indicators were expressed as (±s), and were examined by using t test. The SIRS rate and postoperative complication rate was examined by Chi-square test, P<0.05 was considered as statistically significant difference.

The operation time, length of incision, intraoperative blood loss, first anal exhaust time, VAS score, ground activity time, diet recovery time and average hospitalization time in laparoscopic group were significantly better than those in open group (P<0.05); There was no significant difference of postoperative complication rate between the two groups (P>0.05). The levels of CRP, IL-6 in serum at 1st, 3rd, 5th day and SIRS rate within 7days after the operation in laparoscopic group were significantly lower than those in open group (P<0.05).

Laparoscopic cholecystectomy in treatment of acute calculous cholecystitis is feasible and safe with the advantage of shorter operative time, less intraoperative bleeding, faster postoperative recovery and light inflammatory reaction, which is valuable to be applied in clinic.