To explore the feasibility and effectiveness of a standardized parenteral nutrition (PN) treatment process constructed based on an informatized whole-process nutrition management system, evaluate its value in optimizing the rationality of PN prescriptions, improving treatment efficacy, and reducing adverse reactions, and provide a reference for establishing a safer and more effective informatized whole-process nutrition management system for standardized PN treatment processes.

A single-center prospective randomized cluster-controlled study was conducted. A total of 210 patients who required PN support after gastric cancer resection from May to October 2022 were enrolled. A randomized block design was adopted, with the ward medical team as the blocking factor. One group was randomly selected as the intervention group (n=105), and the other groups served as the control group (n=105). In the intervention group, clinical pharmacists formulated PN regimens in accordance with the established standardized PN treatment process; in the control group, clinical physicians formulated PN regimens based on conventional experience. Statistical analysis of data was performed using SPSS 26.0 software. Data were expressed as (±s) or [cases (%)], and independent samples t test or χ² test was used for comparison. P<0.05 was considered statistically significant.

After PN treatment: In the control group, levels of creatinine, hemoglobin, and blood potassium decreased, while levels of estimated glomerular filtration rate (eGFR), triglycerides, platelets, blood sodium, and blood calcium increased (all P<0.05). The intervention group showed the same changing trend of the above indicators as the control group; additionally, levels of aspartate aminotransferase (AST) and total bilirubin decreased, and albumin level increased (all P<0.05). Inter-group comparison showed that levels of albumin, blood phosphorus, and blood potassium in the intervention group were higher than those in the control group (all P<0.05). Compared with the control group, the intervention group had significantly better outcomes in terms of average blood glucose level, daily maximum blood glucose value, and blood glucose fluctuation range (all P<0.05). The incidence of hyponatremia, hypophosphatemia, and hyperglycemia in the intervention group was lower (all P<0.05). There were no cases of unreasonable energy and fluid volume in the intervention group, which was significantly better than the control group (P<0.05). The intervention group had earlier times of first postoperative flatus and defecation, and fewer hospital stays, but the differences were not statistically significant (all P>0.05).

The standardized PN formulation process constructed based on the informatized whole-process nutrition management system significantly improves the rationality of PN prescriptions and enhances the control of patients’ blood glucose and electrolytes, providing a reference for the implementation of a more standardized and comprehensive informatized whole-process nutrition management.