To explore the effect of laparoscopic mesenteric resection via the combined median-caudal approach on inflammatory and stress responses in patients with right-sided colon cancer complicated by intestinal obstruction.

A retrospective analysis was conducted on the clinical data of 138 patients with right-sided colon cancer complicated by intestinal obstruction who were treated from August 2023 to August 2024. According to the different surgical approaches, the patients were divided into a control group and a study group, with 69 cases in each group. Patients in the control group received the traditional cranial-median approach during surgery, while those in the study group received the combined median-caudal approach. Statistical software SPSS 23.0 was used for data analysis. Measurement data were described as(±s) and analyzed by t test; count data were described as percentages (%) and analyzed by χ² test. Surgical indicators, inflammatory factors, stress responses (before and after surgery), and complications were compared between the two groups. P<0.05 was considered statistically significant.

The intraoperative blood loss and operation time of the study group were lower than those of the control group (P<0.05). After surgery, the serum levels of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), norepinephrine (NE), adrenaline (AD), and cortisol (Cor) in both groups were higher than those before surgery, and the above indicators in the study group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of postoperative adverse complications between the two groups (2.9% vs. 1.4%, P>0.05).

For patients with right-sided colon cancer complicated by intestinal obstruction, laparoscopic mesenteric resection via the combined median-caudal approach can effectively reduce the postoperative inflammatory level and stress response of the body, accelerate the postoperative recovery process of patients, and has high clinical application value.