To compare the short-and mid-term efficacy of laparoscopic radical resection for right-sided colon cancer via the "Hui" -shaped inferior right approach and the conventional median approach.

Clinical data of 81 patients with right-sided colon cancer who underwent laparoscopic radical resection for colon cancer were collected. According to the surgical approach, the patients were divided into the median approach group (n=40) and the inferior right approach group (n=41). Statistical software SPSS 25.0 was used for data analysis. Measurement data, such as perioperative indicators and gastrointestinal hormones, were expressed as (±s) and analyzed by independent samples t test; count data, including postoperative complications and disease-free survival rate, were analyzed by χ² test. P<0.05 was considered statistically significant.

Compared with the median approach group, the inferior right approach group had less intraoperative blood loss, and shorter operation time and time to first flatus (all P<0.05). After surgery, the serum levels of gastrin (GAS) and motilin (MOT) in both groups were lower than those before surgery, while the levels in the inferior right approach group were higher than those in the median approach group (P<0.05). The total incidence of postoperative complications was 4.9% in the inferior right approach group and 7.5% in the median approach group, with no statistically significant difference between the two groups (P>0.05). The 1-year and 3-year disease-free survival rates were 92.7% vs. 87.5% and 65.9% vs. 60.0% in the inferior right approach group and the median approach group, respectively, and there were no statistically significant differences between the two groups (P>0.05).

Both laparoscopic radical resection via the "Hui" -shaped inferior right approach and the conventional median approach are safe and feasible for the treatment of right-sided colon cancer. However, compared with the latter, the former has lower surgical difficulty, shorter operation time, less intraoperative blood loss, and faster postoperative recovery.