Abstract:

Objective

To analyze the risk factors for primary liver cancer complicating hepatitis B virus （HBV）-related liver cirrhosis，so as to provide a reference for clinical diagnosis and treatment.

Methods

The data of 76 patients with primary liver cancer complicating HBV-related liver cirrhosis from July 2018 to July 2023 were retrospectively analyzed and set as the study group.Another 84 patients with HBV-related liver cirrhosis admitted during the same period were selected as the control group.The statistical software SPSS 23.0 was used for univariate analysis and multivariate Logistic regression analysis of the risk factors for primary liver cancer.

Result

Univariate analysis showed that the proportions of male gender，age ≥ 65 years old，family history of liver cancer，long-term drinking history，no antiviral treatment，and HBV-DNA quantification ＞ 2×10² IU/ml in the study group were all higher than those in the control group，and the differences were statistically significant （P＜0.05）.Incorporating the above factors with differences into the multivariate Logistic regression analysis showed that male gender，age ≥ 65 years old，family history of liver cancer，long-term drinking history，no antiviral treatment，and HBV-DNA quantification ＞ 2×10² IU/ml were independent risk factors for liver cancer complicating HBV-related liver cirrhosis （P＜0.05）.

Conclusion

There are many risk factors for primary liver cancer complicating HBV-related liver cirrhosis，and high-risk patients should be given special attention in clinical practice.

Key words: Hepatitis B Virus, Liver Cirrhosis, Primary Liver Cancer, Logistic Regression Analysis of Risk Factors