To investigate the correlation between ultrasound signs and the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), Ki67 antigen and other molecular biological indicators in elderly non-specific invasive breast cancer (IBC-NST).

The MRI findings (mass size, shape, margin, microcalcification, blood flow distribution) and molecular biological indicators of 82 patients with pathologically confirmed IBC-NST from May 2017 to August 2019 were retrospectively analyzed. SPSS21.0 statistical software was used for analysis. The counting data were represented by [n (%)] and tested. Measurement data were expressed as () and t test was adopted. P<0.05 was considered to be statistically significant.

The tumor size was correlated with the positive expression of ER, PR, HER-2 and Ki-67, the burr sign of tumor margin was correlated with the positive expression of ER and PR, and the microcalcification in tumor was correlated with the positive expression of HER-2 and Ki-67 (P<0.05). Tumor morphology, posterior echo and blood flow distribution were not significantly correlated with the expression of ER, PR, HER-2 and Ki-67 (P> 0.05).

IBC-NST ultrasound signs are obviously correlated with molecular biological indicators. By analyzing the ultrasonic characteristics of IBC-NST, the biological behavior of tumor can be evaluated, and it has certain reference value for guiding clinical treatment and judging prognosis.