Accelerated rehabilitation surgery in obstructive jaundice：metabolic interactions between bile acids and intestinal microbes

doi:10.3877/cma.j.issn.1674-3946.2023.02.029

Abstract

Abstract:

Obstructive jaundice is characterized by rapid disease progression，more complications and long hospital stay. The main treatment for the disease is to remove the obstruction. The recovery of liver function begins after the obstruction is relieved，but the recovery process is relatively long，and bile acids can be used as an indicator of the recovery of liver function. Bile acid is one of the main components of bile，which is responsible for digestion and messenger function. Bile acids are also closely related to gut microbes，based on the particular anatomy of the hepatobiliary system connected to the gut. Although bile acids and gut microbes have been studied for decades，their specific interactions and biological functions are not fully understood. In this review，the metabolic process of bile acids is mainly described，and the mechanism of how bile acids are regulated by intestinal microbiome is emphasized，that is，how intestinal microorganisms affect bile acid composition through metabolic capacity，and how external factors affect intestinal microbiome and thus bile acid composition. These mechanisms have led to therapies targeting intestinal microbiome and bile acid metabolism disorders and accelerated postoperative recovery from obstructive jaundice.

Key words: Jaundice, Obstructive, Bile Acids, Gut Microbiota, Enhanced Recovery After Surgery, Metabolism

Shiyang Yu, Dagang Yang, Yongning Li, Xianqiu Xiong, Futang Li, Rong Wang. Accelerated rehabilitation surgery in obstructive jaundice：metabolic interactions between bile acids and intestinal microbes[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(02): 230-234.

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