The role of autophagy in sepsis and progress in targeted therapy

doi:10.3877/cma.j.issn.1674-3946.2023.02.027

Abstract

Abstract:

Sepsis is currently defined as life-threatening organ dysfunction caused by the host’s maladjusted response to infection. The specific pathogenesis has not been fully elucidated. Autophagy，as an important form of relatively conservative regulation of cell state among various species，is the body’s response to external stimuli in the form of phagocytosis of foreign pathogens，damaged organelles and degradation of inactivated proteins to maintain the internal homeostasis of cells and relieve multiple organ dysfunction caused by sepsis（MODS）. Immune cell dysfunction is considered to be the main cause of poor prognosis in patients with sepsis，and specific treatment is still lacking. There is evidence that activation of autophagy with multiple drugs can effectively relieve sepsis，improve immune function and improve survival rate. Regulating autophagy mechanism may be a new therapeutic strategy to reverse immunosuppression in sepsis patients.

Key words: Sepsis, Autophagy, Immunosuppression, Targeted Therapy

Wentao Zhong, Yang Zhao, Xiaofei Shen, Junfeng Du. The role of autophagy in sepsis and progress in targeted therapy[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(02): 221-225.

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References 53

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药物	机制	参考文献
丙戊酸	降低小鼠死亡率；改善心肌损伤；缓解线粒体损伤；减少炎症因子表达；增加PTEN表达	^[7]
氢气	提高小鼠存活率；减轻脓毒症导致的MODS；减轻内质网应激（ERS）	^[51]
褪黑素	增加心肌中SIRT1的表达；减少心肌细胞凋亡，改善心脏功能	^[6]
京尼平	提高小鼠存活率；减轻MODS；降低p62表达	^[52]
超顺磁性氧化铁纳米粒子（SPIONs）	缓解肝损伤；增加IL-10表达	^[53]

药物	机制	参考文献
丙戊酸	降低小鼠死亡率；改善心肌损伤；缓解线粒体损伤；减少炎症因子表达；增加PTEN表达	^[7]
氢气	提高小鼠存活率；减轻脓毒症导致的MODS；减轻内质网应激（ERS）	^[51]
褪黑素	增加心肌中SIRT1的表达；减少心肌细胞凋亡，改善心脏功能	^[6]
京尼平	提高小鼠存活率；减轻MODS；降低p62表达	^[52]
超顺磁性氧化铁纳米粒子（SPIONs）	缓解肝损伤；增加IL-10表达	^[53]

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