To investigate the effect of anatomic hepatectomy（AR）and non-anatomic hepatectomy（NAR）led by the third liver pedicle on the prognosis of liver cancer patients.

The clinical data of 89 patients with primary liver cancer who underwent hepatectomy from July 2015 to December 2017 were retrospectively analyzed. According to different surgical methods，they were divided into AR group（n=45）and NAR group（n=44）. The data were processed by SPSS 22.0 software. The perioperative indicators and liver zymogram changes of the two groups were expressed as（

The blood loss and positive rate of surgical margin in AR group were significantly lower than those in NAR group（blood loss：414 ml vs. 973 ml，P<0.01；The positive rate of surgical margin was 0% vs. 10%，P=0.056），and the recurrence rate at 6 and 12 months after surgery was significantly lower than that in the NAR group（6.7% vs. 20.5%，P=0.058；15.6% vs. 40.9%，P=0.008）；The operation time in AR group was significantly longer than that in NAR group（325 min vs. 270 min，P=0.041）. The liver function of AR group was less affected after operation（P<0.01），and the comparison between the two groups was statistically significant. There was no significant difference in the incidence of postoperative serious complications between the two groups（P>0.05）.

Compared with non-anatomical hepatectomy，anatomical hepatectomy led by the third hepatic pedicle is a more appropriate surgical method for the treatment of liver cancer，with less intraoperative blood loss，less postoperative liver function impact，and lower postoperative recurrence rate.