To investigate the application effect of different lymph node tracing schemes in laparoscopic splenic hilar lymph node dissection of proximal gastric cancer with splenic preservation.

The clinical data of 133 patients who underwent laparoscopic proximal radical gastrectomy for gastric cancer from June 2016 to December 2020 were retrospectively analyzed. The patients were divided into carbon nanoscale group（n=91）and ICG group（n=42）according to different lymph node tracing schemes used during operation. Statistical software SPSS 24.0 was used for clinical data analysis. Measurement data such as perioperative indicators and lymph node dissection were expressed as（

The operation time and splenic hilar lymph node dissection time in ICG group were shorter than those in nano-carbon group（P<0.05）. There were no significant differences in intraoperative blood loss，postoperative exhaust time and postoperative hospital stay between the two groups（P>0.05）. The incidence of postoperative complications was 12.1% in the carbon nanoscale group and 14.3% in the ICG group，and there was no significant difference between the two groups（P>0.05）. There were no significant differences in lymph node tracing effect，number of dissected lymph nodes，positive rate of lymph node detection，number of splenic hilar lymph nodes dissected，and positive rate of splenic hilar lymph nodes between the two groups（P>0.05）. The median follow-up time was 31 months until July 2021. There was no significant difference in the 3-year cumulative survival rate between the two groups（63.7% vs. 58.8%，P>0.05）.

Both carbon nanoparticles and ICG tracer schemes have good application value in laparoscopic splenic hilar lymph node dissection of proximal gastric cancer with splenic preservation. ICG has more prominent visual effect，can shorten the operation time and splenic hilar lymph node dissection time，and the price is low，which has certain advantages.