Research progress on the relationship between one carbon metabolism and colorectal cancer

doi:10.3877/cma.j.issn.1674-3946.2021.04.032

Abstract

Abstract:

One carbon unit can be used for nucleotide synthesis, substrate methylation and reductionism, while one carbon metabolism, including serine metabolism, glycine metabolism, methionine cycle and folic acid cycle, maintains intracellular homeostasis and genetic stability, and to a certain extent support the tumorigenesis and development of cancer. Colorectal cancer (CRC) is a common but unclear malignant tumor with a high morbidity and mortality. Many recent studies have shown that the one carbon metabolism is closely related to colorectal cancer, and its metabolism-related genes, metabolic substrates and metabolites have also become new tumor diagnostic markers, prognostic markers and therapeutic targets. Therefore, this article reviews the research progress on the relationship between one-carbon metabolism and colorectal cancer, providing insight for the further research.

Key words: Colorectal neoplasms, Metabolism, One-carbon unit

Xuening Dang, Xiaojian Chen, Long Cui. Research progress on the relationship between one carbon metabolism and colorectal cancer[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2021, 15(04): 468-472.

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