To analyze the quality of life and survival rate of patients with advanced gastric cancer treated by neoadjuvant chemotherapy combined with laparoscopic radical gastrectomy

172 patients with advanced gastric carcinoma treated in the hospital from August 2012 to August 2015 were retrospectively analyzed, and they were divided into control group (86 cases) and SOX group (86 cases) according to the randomized controlled method. Both the two groups received laparoscopic radical gastrectomy, and two cycles of enteral nutrition and neoadjuvant chemotherapy before surgery were given in the SOX groups. The data were processed by SPSS 25 software. Perioperative nutritional index, quality of life as (±s) were compared using the independent t test. The short-term curative effect, R0 resection rate and survival rate were compared by χ² test, P<0.05 was statistically significant.

The total effective rate, disease control rate and R0 resection rate in SOX group (58.1%, 89.5%, 70.9%) were higher than those in control group (43.0%, 75.6%, 55.8%) (P<0.05); The levels of postoperative 7 d serum albumin (Alb), prealbumin (PA), hemoglobin (Hb) in the two groups were lower than those before surgery, and the above indexes in SOX group were higher than those in control group (P<0.05); The score of MOS item short from health survey (SF-36) in SOX group was higher than that in control group, the three-year overall survival rate and postoperative third-year disease-free survival rate in SOX group (77.9%, 74.4%) were higher than those in control group (60.5%, 59.3%) (P<0.05).

Neoadjuvant chemotherapy combined with laparoscopic radical resection of gastric cancer in treatment of advanced gastric cancer is effective, which can improve the resection rate and survival rate, improve the quality of life; chemotherapy received standard enteral nutrition can improve the nutritional status.