To explore the effect of laparoscopic cholecystectomy (LC) combined with endoscopic retrograde cholangiopancreatography (ERCP) at different operation time for cholecystolithiasis combined with choledocholithiasi and the incidence of acute pancreatitis and hyperamylasemia.

From September 2015 to September 2016, 98 patients with cholecystolithiasis combined with choledocholithiasi were randomly divided into observation group (49 cases) and, into the control group (49 cases). The patients in the observation group received ERCP+ EST before LC, while those in the control group underwent ERCP+ EST after LC. SPSS 20.0 software was used for data analysis. Measurement data such as perioperative related indicators and liver functions were expressed as (±s) and were examined by independent t test. The success rate and complication rate were examined by chi square test. A P value of <0.05 was considered as statistically significant.

There were no significant difference in the intraoperative blood loss, the success rate of stone removal, hospitalization, exhaust and average operation time between the two groups (P>0.05). There were no significant difference in liver functions of ALP, ALB, TB and ALT between the two groups at 1 day before operation and 3 days after operation (P>0.05). The acute pancreatitis, hyperamylasemia, fever and elevated white blood cell in the observation group were significantly better than those in the control group respectively (P<0.05).

ERCP + EST before LC in the treatment of cholecystolithiasis combined with choledocholithiasis has the advantages of shorter hospitalization time and less complications, which is worthy of clinical application.