To investigate the influence of incision infection on coagulation and fibrinolysis and lymphedema after breast surgery.

From January 2016 to May 2018, clinical data of 86 patients underwent radical mastectomy were retrospectively analyzed. 34 patients with postoperative incision infection were divided into observation group and 52 patients with postoperative incision uninfected into control group. Statistical analysis were performed by using SPSS21.0 software. The indexes of coagulation and fibrinolysis, the time of occurrence of upper limb lymphedema, the parameters of platelet and the level of serum cytokines were expressed as mean±standard deviation and were examined by independent t test. The incidence of upper limb lymphedema was examined by χ² test (P<0.05).

The time of PT、APTT in infection group were significantly lower than those in the uninfected group, the level of D-D and FIB were significantly higher than those of non-infected group, with significant difference (P<0. 05). The incidence of upper limb lymphedema in infected group was significantly higher than that in uninfected group. The time of upper limb lymphedema was significantly shorter than that in uninfected group (P<0.05). The level of PDW、MPV and PCT in infected group were significantly higher than those in uninfected group (P<0. 05). The levels of IL-4, IL-6, IL-10, TNF-α and IFN-γ in infected group were significantly higher than those in uninfected group (P<0.05).

Incision infection after radical mastectomy could lead to elevated levels of inflammatory factors, fibrinolysis and abnormal platelet parameters, which are closely correlated to the incidence of upper limb lymphedema of patients.