To explore the clinical efficacy of early operation for severe biliary obstructive pancreatitis and its effects on patients’ serum macrophage inflammatory protein-1 alpha (MIP-1-Alpha), macrophage inflammatory protein-1 beta (MIP-1 beta) and monocyte chemotactic factor protein 1 (MCP 1).

Clincal data of 96 patients with severe biliary obstructive pancreatitis from August 2014 to August 2017 were analyzed retrospectively. By using random digital table, the patients were divided into the delayed operation group (n=48, the onset to operation >12 h), and the early operation group (the onset to operation less than 12 h) . The SPSS20.0 software was used for data analysis. Perioperative measurement data and serum index were expressed as (±s), and were examined by using t test.The postoperative complication rate and satisfaction rate were analyzed by Chi-square test. A P value <0.05 was considered as statistically significant difference.

The hospital stay, postoperative drainage and postoperative complications in the early surgical group were significantly lower than those in delayed operation group (P<0.05). Compared with the preoperative data, postoperative serum MIP-1 alpha, beta and MIP-1 MCP-1 levels were significantly decreased in both two groups (P<0.05). Compared with delayed operation group, peroperative changes of serum levels in early surgical group were significantly increased (P<0.05).

Early operation has significant effect on severe biliary obstruction type pancreatitis. The serum mip-1, mip-1 and McP-1 levels could be significantly reduced, and should be promoted in clinical practice.