With the rapid development of laparoscopic pancreatic surgery, laparoscopic pancreaticoduodenectomy have been performed gradually in some pancreatic centers in China. Resection of uncinate process is a key step of laparoscopic pancreaticoduodenectomy which greatly affects duration of operation, blood loss and R0 resection rate. One of challenges in laparoscopic pancreaticoduodenectomy is uncinate process resection. However, recent methods of uncinate process resection in laparoscopic pancreaticoduodenectomy have both advantages and disadvantages. Based on our own experience, the author summarizes a new method of uncinate process resection by using anterior "vein-first" combined with right posterior "artery-first" approach in laparoscopic pancreaticoduodenectomy. This approach could shorten the operation time, reduce blood loss and could increase R0 resection rate, with obvious superiority and safety in laparoscopic pancreaticoduodenectomy in clinical setting.