| ［1］ |
张太平，申鹏，赵玉沛. 不断提高胰腺癌诊治规范化水平［J/CD］. 中华普外科手术学杂志（电子版），2015, 9（04）: 231-234.
|
| ［2］ |
国家卫生健康委办公厅. 胰腺癌诊疗指南（2022年版）［J］. 临床肝胆病杂志,2022, 38（05）: 1006-1030.
|
| ［3］ |
Alon-Maimon T，Mandelboim O，Bachrach G.Fusobacterium nucleatum and cancer［J］. Periodontol 2000, 2022, 89（1）: 166-180.
|
| ［4］ |
Quaglio AEV，Grillo TG，De Oliveira ECS，et al. Gut microbiota，inflammatory bowel disease and colorectal cancer［J］. World J Gastroenterol，2022, 28（30）: 4053-4060.
|
| ［5］ |
Kunovsky L，Dite P，Jabandziev P，et al. Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis［J］. World J Gastrointest Oncol，2021, 13（8）: 835-844.
|
| ［6］ |
Bellotti R，Speth C，Adolph TE，et al. Micro- and Mycobiota Dysbiosis in Pancreatic Ductal Adenocarcinoma Development［J］. Cancers（Basel），2021, 13（14）: 3431.
|
| ［7］ |
赖冰，刘璐，谢建军，等. 具核梭杆菌与结直肠癌的关系及其临床意义［J］. 现代肿瘤医学，2022, 30（15）: 2860-2863.
|
| ［8］ |
Meng Q，Gao Q，Mehrazarin S，et al. Fusobacterium nucleatum secretes amyloid-like FadA to enhance pathogenicity［J］. EMBO Rep，2021, 22（7）: e52891.
|
| ［9］ |
Lopez LR，Bleich RM，Arthur JC. Microbiota Effects on Carcinogenesis: Initiation，Promotion，and Progression［J］. Annu Rev Med，2021, 72:243-261.
|
| ［10］ |
Mitsuhashi K，Nosho K，Sukawa Y，et al. Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis［J］. Oncotarget，2015, 6（9）: 7209-7220.
|
| ［11］ |
Kohi S，Macgregor-das A，Dbouk M，et al. Alterations in the Duodenal Fluid Microbiome of Patients With Pancreatic Cancer［J］. Clin Gastroenterol Hepatol，2022, 20（2）: e196-e227.
|
| ［12］ |
Chung M，Zhao N，Meier R，et al. Comparisons of oral，intestinal，and pancreatic bacterial microbiomes in patients with pancreatic cancer and other gastrointestinal diseases［J］. J Oral Microbiol，2021, 13（1）: 1887680.
|
| ［13］ |
Del Castillo E，Meier R，Chung M，et al. The Microbiomes of Pancreatic and Duodenum Tissue Overlap and Are Highly Subject Specific but Differ between Pancreatic Cancer and Noncancer Subjects［J］. Cancer Epidemiol Biomarkers Prev，2019, 28（2）: 370-383.
|
| ［14］ |
Nejman D，Livyatan I，Fuks G，et al. The human tumor microbiome is composed of tumor type-specific intracellular bacteria［J］. Science，2020, 368（6494）: 973-980.
|
| ［15］ |
Guo P，Tian Z，Kong X，et al. FadA promotes DNA damage and progression of Fusobacterium nucleatum-induced colorectal cancer through up-regulation of chk2［J］. J Exp Clin Cancer Res，2020, 39（1）: 202.
|
| ［16］ |
Parhi L，Abed J，Shhadeh A，et al. Placental colonization by Fusobacterium nucleatum is mediated by binding of the Fap2 lectin to placentally displayed Gal-GalNAc［J］. Cell Rep，2022, 38（12）: 110537.
|
| ［17］ |
Casasanta MA，Yoo CC，Udayasuryan B，et al. Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration［J］. Sci Signal，2020, 13（641）: eaba9157.
|
| ［18］ |
Parhi L，Alon-Maimon T，Sol A，et al. Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression［J］. Nat Commun，2020, 11（1）: 3259.
|
| ［19］ |
毛旭虎，童亚楠. 具核梭杆菌研究进展［J］. 第三军医大学学报，2019, 41（19）: 1867-1872.
|
| ［20］ |
Kurtzman GM，Horowitz RA，Johnson R，et al. The systemic oral health connection: Biofilms［J］. Medicine（Baltimore），2022, 101（46）: e30517.
|
| ［21］ |
Wu J，Li Q，Fu X. Fusobacterium nucleatum Contributes to the Carcinogenesis of Colorectal Cancer by Inducing Inflammation and Suppressing Host Immunity［J］. Transl Oncol，2019, 12（6）: 846-851.
|
| ［22］ |
Teles FRF，Alawi F，Castilho RM，et al. Association or Causation？Exploring the Oral Microbiome and Cancer Links［J］. J Dent Res，2020, 99（13）: 1411-1424.
|
| ［23］ |
Geng F，Zhang Y，Lu Z，et al. Fusobacterium nucleatum Caused DNA Damage and Promoted Cell Proliferation by the Ku70/p53 Pathway in Oral Cancer Cells［J］. DNA Cell Biol，2020, 39（1）: 144-151.
|
| ［24］ |
Schwabe RF，Jobin C. The microbiome and cancer［J］. Nat Rev Cancer，2013, 13（11）: 800-812.
|
| ［25］ |
Wu J，Wang Y，Jiang Z. Immune induction identified by TMT proteomics analysis in Fusobacterium nucleatum autoinducer-2 treated macrophages［J］. Expert Rev Proteomics，2020, 17（2）: 175-185.
|
| ［26］ |
Udayasuryan B，Ahmad RN，Nguyen TTD，et al. Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling［J］. Sci Signal，2022, 15（756）: eabn4948.
|
| ［27］ |
Alkharaan H，Lu L，Gabarrini G，et al. Circulating and Salivary Antibodies to Fusobacterium nucleatum Are Associated With Cystic Pancreatic Neoplasm Malignancy［J］. Front Immunol，2020, 11:2003.
|
| ［28］ |
Riccardi C，Napolitano E，Platella C，et al. Anti-VEGF DNA-based aptamers in cancer therapeutics and diagnostics［J］. Med Res Rev，2021, 41（1）: 464-506.
|
| ［29］ |
Propper DJ，Balkwill FR. Harnessing cytokines and chemokines for cancer therapy［J］. Nat Rev Clin Oncol，2022, 19（4）: 237-253.
|
| ［30］ |
Xiao Y，Cong M，Li J，et al. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation［J］. Cancer Cell，2021, 39（3）: 423-437.e7.
|
| ［31］ |
Pretre V，Papadopoulos D，Regard J，et al. Interleukin-1（IL-1）and the inflammasome in cancer［J］. Cytokine，2022, 153:155850.
|
| ［32］ |
Demling A，Demling C，Schwestka-polly R，et al. Influence of lingual orthodontic therapy on microbial parameters and periodontal status in adults［J］. Eur J Orthod，2009, 31（6）: 638-642.
|
| ［33］ |
郭杨，张玉杰，肖水清. 具核梭杆菌生物学特性及检测手段的研究进展［J］. 国际口腔医学杂志，2012, 39（06）: 770-774.
|
| ［34］ |
Kim HS，Song SK，Yoo SY，et al. Development of strain-specific PCR primers based on a DNA probe Fu12 for the identification of fusobacterium nucleatum subsp. nucleatum ATCC 25586T［J］. J Microbiol，2005, 43（4）: 331-336.
|
| ［35］ |
Suchett-kaye G，Morrier JJ，Barsotti O. Clinical usefulness of microbiological diagnostic tools in the management of periodontal disease［J］. Res Microbiol，2001, 152（7）: 631-639.
|
| ［36］ |
Boutaga K，Van Winkelhoff AJ，Vandenbroucke-grauls CM，et al. The additional value of real-time PCR in the quantitative detection of periodontal pathogens［J］. J Clin Periodontol，2006, 33（6）: 427-433.
|
| ［37］ |
赵建国，廖泉，赵玉沛. 胰腺癌分子标志物研究进展［J/CD］. 中华普外科手术学杂志（电子版），2013, 7（03）: 224-226.
|