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中华普外科手术学杂志(电子版) ›› 2019, Vol. 13 ›› Issue (01) : 48 -50. doi: 10.3877/cma.j.issn.1674-3946.2019.01.016

所属专题: 文献

论著

改良根治术与保乳手术治疗早期乳腺癌患者的近远期疗效对照比较
朱辉琴1,(), 陈卫军1, 朱建华1, 胡阳英2, 汪海波3   
  1. 1. 224200 东台市人民医院普外科
    2. 310000 浙江大学国际医院普外科
    3. 310000 浙江大学医学院附属第一医院肿瘤科
  • 收稿日期:2018-09-30 出版日期:2019-02-26
  • 通信作者: 朱辉琴

Comparative study of short-term and long-term clinical outcome of modified radical mastectomy and breast conserving surgery in treating early staging breast cancer

Huiqin Zhu1,(), Weijun Chen1, Jianhua Zhu1, Yangying Hu2, Haibo Wang3   

  1. 1. Department of general surgery, Dongtai people’s Hospital, Zhejiang 224200, China
    2. Department of general surgery, Zhejiang University International Hospital, Zhejiang 310000, China
    3. Department of oncology, the First Affiliated Hospital, Zhejiang University, Zhejiang 310000, China
  • Received:2018-09-30 Published:2019-02-26
  • Corresponding author: Huiqin Zhu
  • About author:
    Corresponding author: Zhu Huiqing, Email:
  • Supported by:
    General research program (Class B) of health care of Zhejiang province(No.2015KYB159)
引用本文:

朱辉琴, 陈卫军, 朱建华, 胡阳英, 汪海波. 改良根治术与保乳手术治疗早期乳腺癌患者的近远期疗效对照比较[J/OL]. 中华普外科手术学杂志(电子版), 2019, 13(01): 48-50.

Huiqin Zhu, Weijun Chen, Jianhua Zhu, Yangying Hu, Haibo Wang. Comparative study of short-term and long-term clinical outcome of modified radical mastectomy and breast conserving surgery in treating early staging breast cancer[J/OL]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2019, 13(01): 48-50.

目的

比较改良根治术与保乳手术治疗早期乳腺癌患者的近远期疗效。

方法

收集2011年6月至2014年1月早期乳腺癌的患者134例,采用随机数字表法将其分为根治组与保乳组,分别采用改良根治术与保乳手术进行治疗,采用SPSS19.0软件进行分析,术中术后指标和生活质量评分采用均数±标准差进行描述,采用独立t检验;1年和3年总生存率和无病生存率、并发症采用率进行描述,采用χ2检验;采用log-rank检验法对两组患者的生存率进行检验,检验水准为α=0.05。

结果

根治组患者术中的平均出血量低于保乳组,且手术时间和术后的平均住院天数均少于保乳组,根治组患者的生理职能和精神健康得分低于保乳组,差异均具有统计学意义(P<0.05);根治组患者的3年无病生存率和3年总生存率均高于保乳组(P<0.05);根治组患者的腋窝淋巴结转移率低于保乳组,差异具有统计学意义(P<0.05)。

结论

改良根治术治疗早期乳腺癌患者的近期疗效和远期疗效均优于保乳手术,腋窝淋巴结的转移率低于保乳手术,更为安全有效,推荐在临床上使用。

Objective

To compare the short-term and long-term clinical outcome of modified radical mastectomy and breast conserving surgery in treating early staging breast cancer.

Methods

134 patients with early staging breast cancer were enrolled into this study, including radical group and breast conserving group by using random number table method. Clinical data were analyzed by using statistical software SPSS 19.0. Measurement data such as perioperative indicators and life quality score were expressed as mean±standard deviation, and independent t test was used for comparison between the groups. Count data, such as 1 year-, 3 year-OS/DFS and postoperative complication rate were examined by using χ2 and log-rank test (α=0.05). A P value <0.05 was considered as statistically significant difference.

Results

The average blood loss in the radical group was lower than that in the breast conserving group, and the operation time and the average postoperative hospital stay were less than those in the breast conserving group, the scores of physiological function and mental health in the radical group were lower than those in the breast conserving group, with significant differences (P<0.05); the 3-year disease-free survival rate and the 3-year overall survival rate in the radical group were higher than those in the breast conserving group, with significant differences (P<0.05); the axillary lymph node metastasis rate in the radical group was lower than that in the breast conserving group, with significant difference (P<0.05).

Conclusion

The short-term and long-term clinical outcome of modified radical mastectomy for breast cancer patients are better than breast conserving surgery, the axillary lymph node metastasis rate is lower than the breast conserving surgery. It is safer and more effective and worth of clinical promotion.

表1 134例早期乳腺癌患者不同手术方法两组患者一般资料比较(±s)
表2 134例早期乳腺癌患者不同手术方法两组患者术中术后指标比较(±s)
表3 134例早期乳腺癌患者不同手术方法两组患者术后生活质量的评价(±s)
表4 134例早期乳腺癌患者不同术式两组患者总生存率和无病生存率比较
表5 134例早期乳腺癌患者不同手术方法两组患者术后并发症比较(例)
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