In recent years, laparoscopic pancreaticoduodenectomy (LPD) for pancreatic head cancer has developed rapidly in China. However, pancreatic head cancer is characterized by easy invasion of surrounding vascular nerve plexus, high propensity for lymphatic metastasis, and frequent association with chronic pancreatitis. Additionally, the evolution of treatment concepts and the increase in surgical cases following neoadjuvant/conversion therapy have posed numerous challenges to the implementation of LPD. Rapidly overcoming the learning curve, defining a reasonable radical resection margin, and performing simple, efficient, and safe pancreaticojejunostomy are crucial for ensuring surgical safety and ultimately benefiting patients. Standardized training and quality control will further promote the popularization and development of LPD, thereby improving patient outcomes.