Abstract:
Objective
To compare the clinical effect of two kinds of operation on intrahepatic cholangiocarcinoma.
Methods
The data of 90 patients with intrahepatic cholangiocarcinoma from December 2018 to December 2023 were retrospectively analyzed.They were divided into two groups according to different operation methods.Laparoscopic hepatectomy was performed in 50 cases and the group was set as endoscopic group.40 patients underwent open liver resection and were set as the open group.SPSS 22.0 statistical analysis data.Perioperative indicators and other measurement data were represented by (x±s), independent sample t test was performed, postoperative complications and other statistical data were represented by［ cases (%)］,χ2 test was used.Kaplan-Meier method was used to calculate the survival rate.P＜0.05 indicated that the difference was statistically significant.
Results
90 patients with intrahepatic cholangiocarcinoma successfully completed hepatectomy without perioperative death.The operative time, intraoperative blood loss, surgical incision, first exhaust time, time to get out of bed and time to stay in the endoscopic group were all better than those in the laparotomy group, with statistical significance (P＜0.05).The total complication rate was lower than that in the open group (6% vs. 15%), and the difference was not statistically significant (P＞0.05).The mean follow-up time was 30.2 months (2～62 months) and the median disease-free survival time (51.1 vs.41.5 months).In the endoscopic group, 33 patients relapsed and 28 died.In the laparotomy group, 28 patients relapsed and 23 died.The 5-year cumulative overall survival rate and disease-free survival rate (44.0% and 34.0%) in the endoscopic group were higher than those in the open group (42.5% and 30%), and the difference was not statistically significant (P＞0.05).
Conclusion
Laparoscopic hepatectomy is safe and effective in the treatment of intrahepatic cholangiocarcinoma, which can shorten operation time, reduce intraoperative bleeding,accelerate postoperative recovery and shorten postoperative hospital stay.The long-term efficacy of laparoscopic hepatectomy is comparable to that of open hepatectomy for intrahepatic cholangiocarcinoma.
Key words:
Intrahepatic Cholangiocarcinoma,
Laparoscopy,
Radical Resection,
The Survival Curve
Yinzhen Pan, Xiuyu Zhang, Yantao Mai, Zhiqiang Liang. Clinical efficacy of two types of operation for intrahepatic cholangiocarcinoma[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2025, 19(02): 208-211.