Recent advancement in understanding STING-mediated mitochondrial DNA in immune responses

doi:10.3877/cma.j.issn.1674-3946.2019.03.033

Abstract

Abstract:

Recent studies reveal that mitochondria plays not only as energy generator but also as immune participant. Mitochondrial DNA recognized by cGAS-STING signaling is involved in various infectious, inflammatory and tumorigenesis events. This review will summarize the molecular signaling of STING-mediated mitochondrial DNA during pathophysiological conditions, explain the mechanism by which mitochondrial DNA induces tumor microenvironment, and discuss how mitochondrial DNA participates in cell apoptosis, autophagy and neutrophil-induced traps.

Key words: DNA, mitochondrial, Autophagy, Apoptosis, Tumor microenvironment

Song Liu, Wenxian Guan. Recent advancement in understanding STING-mediated mitochondrial DNA in immune responses[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2019, 13(03): 320-322.

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