Laparoscopic pancreaticoduodenectomy (LPD) is a complex minimally invasive surgery for treating periampullary and pancreatic head lesions. Although it has advantages such as less trauma and faster recovery, the incidence of postoperative complications is relatively high, which seriously affects the prognosis of patients. From a commentary perspective, this article analyzes the pathogenesis, clinical characteristics and treatment strategies of major complications such as pancreatic fistula, bleeding, biliary fistula and delayed gastric emptying after LPD, and discusses the controversies and progress in current diagnosis and treatment combined with 15 Chinese and English literatures,so as to provide reference for clinical practice.