Analysis of laboratory detection strategies and clinical value for early screening of colorectal cancer

doi:10.3877/cma.j.issn.1674-3946.2025.04.025.

Abstract

Abstract:

Objective

To analyze the laboratory detection strategies and clinical value for the early screening of colorectal cancer (CRC).

Methods

The laboratory detection data of 300 patients with colorectal cancer (colorectal cancer group) admitted to Mentougou Traditional Chinese Medicine Hospital and Mentougou District Hospital from January 2021 to December 2024 and 100 healthy controls (control group) were retrospectively analyzed. The data were processed using SPSS 23.0. Measurement data such as carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), platelet-to-lymphocyte ratio (PLR),and neutrophil-to-lymphocyte ratio (NLR) were expressed as (), and the independent sample t test was used for comparison between groups; Enumeration data were expressed as percentages, and the chi-square test was used. A P value < 0.05 was considered statistically significant.

Results

The positive rate of fecal occult blood test (FOBT) in the colorectal cancer group was 85.3%, and that in the control group was 11.0%, with a statistically significant difference (P<0.05). The levels of CEA and CA19-9, as well as the values of PLR and NLR, were significantly higher than those in the control group (P<0.001); The combined detection of fecal occult blood test (FOBT), tumor markers (CEA, CA19-9), and systemic inflammatory response indicators (PLR,NLR) had a sensitivity of 92.2% and a specificity of 88.5% (AUC=0.933), which was significantly better than single-item detection (P<0.05).

Conclusion

The combined laboratory detection (FOBT + tumor markers +inflammatory indicators) can significantly improve the screening efficiency of colorectal cancer.

Key words: Colorectal Neoplasms, Biomarkers, Tumor, Fecal Occult Blood Test, Early Screening

Xia An, Yusheng Shi, Zhixin Song. Analysis of laboratory detection strategies and clinical value for early screening of colorectal cancer[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2025, 19(04): 446-448.

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URL: https://zhpwkssxzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-3946.2025.04.025.

https://zhpwkssxzz.cma-cmc.com.cn/EN/Y2025/V19/I04/446

Figures/Tables 3

组别	例数	性别（例）	年龄（岁， $\overset{ˉ}{x}$ ± s ）	体质量指数（kg/m²， $\overset{ˉ}{x}$ ± s ）
组别	例数	男/女	年龄（岁， $\overset{ˉ}{x}$ ± s ）	体质量指数（kg/m²， $\overset{ˉ}{x}$ ± s ）
结直肠癌组	300	172/128	61. 0±8. 5	23. 5±2. 8
对照组	100	58/42	60. 0±7. 8	23. 2±2. 5
t/χ ²值		0. 086	0. 894	0. 956
P值		0. 769	0. 373	0. 342

组别	例数	性别（例）	年龄（岁， $\overset{ˉ}{x}$ ± s ）	体质量指数（kg/m²， $\overset{ˉ}{x}$ ± s ）
组别	例数	男/女	年龄（岁， $\overset{ˉ}{x}$ ± s ）	体质量指数（kg/m²， $\overset{ˉ}{x}$ ± s ）
结直肠癌组	300	172/128	61. 0±8. 5	23. 5±2. 8
对照组	100	58/42	60. 0±7. 8	23. 2±2. 5
t/χ ²值		0. 086	0. 894	0. 956
P值		0. 769	0. 373	0. 342

组别	例数	FOBT阳性[例（%）]	CEA(ng/ml， $\overset{ˉ}{x}$ ± s )	CA19-9(U/ml， $\overset{ˉ}{x}$ ± s )
结直肠癌组	300	256(85. 3)	18. 5±12. 3	45. 2±31. 6
对照组	100	11(11. 0)	2. 1±0. 8	15. 8±6. 2
χ ²/t 值		188. 27	13. 310	9. 199
P值		＜0. 001	＜0. 001	＜0. 001
组别	例数	PLR( $\overset{ˉ}{x}$ ± s )	NLR( $\overset{ˉ}{x}$ ± s )
结直肠癌组	300	215. 6±82. 3	3. 8±1. 5
对照组	100	148. 2±56. 7	1. 9±0. 6
χ ²/t 值		7. 640	12. 370
P值		＜0. 001	＜0. 001

组别	例数	FOBT阳性[例（%）]	CEA(ng/ml， $\overset{ˉ}{x}$ ± s )	CA19-9(U/ml， $\overset{ˉ}{x}$ ± s )
结直肠癌组	300	256(85. 3)	18. 5±12. 3	45. 2±31. 6
对照组	100	11(11. 0)	2. 1±0. 8	15. 8±6. 2
χ ²/t 值		188. 27	13. 310	9. 199
P值		＜0. 001	＜0. 001	＜0. 001
组别	例数	PLR( $\overset{ˉ}{x}$ ± s )	NLR( $\overset{ˉ}{x}$ ± s )
结直肠癌组	300	215. 6±82. 3	3. 8±1. 5
对照组	100	148. 2±56. 7	1. 9±0. 6
χ ²/t 值		7. 640	12. 370
P值		＜0. 001	＜0. 001

指标	敏感性（%）	特异性（%）	AUC值
FOBT	78. 4	85. 1	0. 801
CEA	65. 2	80. 1	0. 766
CA19-9	60. 6	75. 1	0. 713
PLR	70. 1	82. 1	0. 734
NLR	68. 4	80. 4	0. 722
FOBT+CEA+CA9-9+PLR+NLR	92. 3	88. 6	0. 934

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