Standardized clinical data is an important basis for high-quality clinical and fundamental research，a powerful guarantee for improving clinical practice，and a basis for clinical decision-making and medical policy formulation. The construction and management of a standardized clinical database can improve the quality of clinical data. Based on the Greater China Metabolic and Bariatric Surgery Database，this paper focuses on the establishment process and practical experience of the clinical database in five aspects：background and purpose，set-up process，quality improvement issues，clinical data protection，and prospects，in the hope of promoting high-quality clinical research and clinical practice in metabolic and bariatric surgery.