Hepatocellular carcinoma（HCC）is one of the most common malignant tumors in China. In recent years，great progress has been made in the field of liver cancer diagnosis and treatment in China，and some medical centers have ranked among the top HCC centers in the world. However，therapeutic effect of HCC in China is unsatisfactory. The 5-year survival rate of Mainland Chinese patients is only 14.1%，which is significantly lower than the average level in East Asia（Close to 30%）. The crux of this lies in the irregularities of prevention，diagnosis and treatment. It is mainly reflected in the lack of cooperation between different departments，uneven distribution of medical resources in different regions，defects in medical quality evaluation system，and insufficient promotion of diagnosis and treatment guideline. It is necessary to promote the standardization of clinical diagnosis and treatment of HCC in China by promoting the multi-disciplinary diagnosis and treatment mode in HCC treatment，balancing the distribution of medical resources，improving the medical quality evaluation system and strengthening the promotion of diagnosis and treatment guidelines.