To investigate the clinical outcome of strap-on pancreaticojejunostomy and modified U-shaped cross-locking pancreaticojejunostomy in pancreaticoduodenectomy under enhanced recovery after surgery (ERAS) principles.

April 2016 to December 2019, clinical data of 92 who received pancreaticoduodenectomy were analyzed retrospectively. Sixty-two patients who received pancreaticoduodenectomy from April 2016 to December 2019 were prospectively selected. According to the surgical methods, 46 cases were divided into the traditional group who treated with bundled pancreaticoenterostomy, and 46 cases were divided into improved group who treated with modified U-shaped cross-locking pancreaticoenterostomy. Statistical software SPSS20.0 were used for data analysis. Measurement data such as intraoperative and postoperative related indexes and serum indexes were expressed as (±s), and were examined by independent test. Chi-square test were performed for analysis of complications. A P value of <0.05 was considered as statistically significant difference.

One week after operation, there were higher levels of total protein (TP), albumin (ALB) and prealbumin (PA) in serum of the modified group than those of the traditional group respectively (P< 0.05). The operative time, intraoperative blood loss, anastomosis time and postoperative hospitalization time in the improved group were significantly shorter than those in the traditional group respectively (P<0.05). The incidence of postoperative complications in the improved group was significantly lower than that in the traditional group (13.0 vs. 30.4%), with significant difference (P<0.05).

Under ERAS principles, subpancreaticoduodenectomy modified U-type through interlocking pancreaticoduodenectomy is a safe and effective method in pancreaticoduodenectomy, which has certain clinical application value.