Adenine nucleotide translocase and cancer cell apoptosis

doi:10.3877/cma.j.issn.1674-3946.2021.01.032

Abstract

Abstract:

Adenine nucleotide translocase is one kind of transport protein in mitochondria. It is related to the metabolism and apoptosis of cancer cells and has certain therapeutic potential for malignant tumors. There were four isomers of ANT with functional difference . In this paper, the relationship between apoptosis of cancer cell and four isomers of ANT are reviewed and discussed .

Key words: Carcinoma, Adenine nucleotides, Apoptosis

Youlei Zhang, Daorong Wang, Chengmin Ma. Adenine nucleotide translocase and cancer cell apoptosis[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2021, 15(01): 111-113.

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References 22

[1]	李燕．腺嘌呤核苷酸转位酶与细胞凋亡[J]．西部医学，2011，23(5): 984-986.
[2]	杨丹琦，王艳宏，李洪晶，等．基于亲脂性阳离子、线粒体靶向信号肽和己糖激酶修饰的线粒体靶向抗肿瘤制剂的研究进展[J]．中国药房，2019，30(2): 272-276.
[3]	Clemencon B, Babot M, Trezeguet V. The mitochondrial ADP/ATP carrier (SLC25 family): pathological implications of its dysfunction[J]. Mol Aspects Med，2013，34(2-3): 485-493.
[4]	Gallerne C, Touat Z, Chen ZX, et al. The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells[J]. Int J Biochem Cell Biol，2010，42(5): 623-629.
[5]	Schwarz M, Andrade-Navarro MA, Gross A. Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program? [J]. Apoptosis，2007，12(5): 869-876.
[6]	Shanmughapriya S, Rajan S, Hoffman NE, et al. SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore[J]. Mol Cell，2015，60(1): 47-62.
[7]	Chevrollier A, Loiseau D, Chabi B, et al. ANT2 isoform required for cancer cell glycolysis[J]. J Bioenerg Biomembr，2005，37(5): 307-316.
[8]	Hu ZL, Guo XQ, Yu Q, et al. Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells[J]. FEBS Lett，2009，583(2): 383-388.
[9]	Chevrollier A, Loiseau D, Reynier P, et al. Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism[J]. Biochim Biophys Acta，2011，1807(6): 562-567.
[10]	Jang JY, Choi Y, Jeon YK, et al. Over-expression of adenine nucleotide translocase 1 (ANT1) induces apoptosis and tumor regression in vivo[J]. BMC Cancer，2008，8: 160.
[11]	Kokoszka JE, Waymire KG, Levy SE, et al.The ADP/ATP translocator is not essential for themitochondrial permeability transition pore[J]. Nature，2004, 427(6973): 461-465.
[12]	Dong YY, Zhuang YH, Cai WJ, et al. The mitochondrion interfering compound NPC-26 exerts potent anti-pancreatic cancer cell activity in vitro and in vivo[J]. Tumour Biol, 2016，37(11): 15053-15063.
[13]	Zhang C, Jiang H, Wang P, et al. Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions[J]. Sci Rep，2017，7: 44708.
[14]	Lee CH, Kim MJ, Lee HH，et al.Adenine Nucleotide Translocase 2 as an Enzyme Related to [18F] FDG Accumulation in Various Cancers[J]. Mole Imaging Biol，2019, 21(4): 722-730.
[15]	Lin C, Gu JY, Wang HJ, et al. Caspase-Dependent Apoptosis Induction via Viral Protein ORF4 of Porcine Circovirus 2 Binding to Mitochondrial Adenine Nucleotide Translocase 3[J]. J Virol，2018，92(10): e00238.
[16]	Yang ZQ, Cheng W, Hong LX, et al. Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells[J]. Mol Biol Cell，2007，18(11): 4681-4689.
[17]	Ramsay EE, Hogg PJ, Dilda PJ. Mitochondrial metabolism inhibitors for cancer therapy[J]. Pharmaceutical Research，2011，28(11): 2731-2744.
[18]	Kim JE, Hwang MH, Lee HW, et al. Combined RNA interference of adenine nucleotide translocase-2 and ganciclovir therapy in hepatocellular carcinoma[J]. Nucl Med Biol，2013，40(8): 987-993.
[19]	Baik SH, Lee J, Lee YS, et al. ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells[J]. Exp Mol Med，2016，48(3): e222.
[20]	Kashiwaya K, Hosokawa M, Eguchi H, et al. Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis[J]. Cancer Sci，2009，100(3): 457-464.
[21]	Choi Y, Lee HW, Lee J, et al. The combination of ANT2 shRNA and hNIS radioiodine gene therapy increases CTL cytotoxic activity through the phenotypic modulation of cancer cells: combination treatment with ANT2 shRNA and I-131[J]. BMC Cancer，2013，13: 143.
[22]	Wu L, Cao KX, Ni ZH, et al. Rhein reverses doxorubicin resistance in SMMC-7721 liver cancer cells by inhibiting energy metabolism and inducing mitochondrial permeability transition pore opening[J]. Biofactors，2019，45(1): 85-96.

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