To investigate the intestinal mucosal barrier function of patients after LPD based on ERAS principles.

A retrospective analysis was performed in 145 patients with LPD from January 2015 to December 2018, who were divided into ERAS group (78 cases) and traditional group (67 cases) according to perioperative treatment protocols. Statistical analysis were performed by using SPSS24.0 software. Measurement data such as perioperative indicators and intestinal mucosal barrier function were represented as (±s) and were examined by using independent t test. Postoperative complications were expressed as n(%) and were analyzed by using χ² test. Kaplan-meier method was used for survival analysis. A P value of <0.05 was considered as statistical significant difference.

The postoperative recovery in the ERAS group were significantly better than those in the traditional group, in terms of first exhaust time, first oral-feeding time, drainage tube extubation time and postoperative hospitalization time (P<0.05). However, there was no significant difference between two groups of mortality rate (P>0.05). The incidence of 3.8% gastric emptying delay in ERAS group (3 cases) was significantly less than 7.5% in traditional group (5 cases), with significant difference (P<0.05). There was no significant difference between two groups of other complications rate (P>0.05). There was no significant difference between two groups of intestinal mucosal barrier function after LPD (P>0.05).

Based on ERAS principles, better clinical effect could be achieved after LPD with improved intestinal mucosal barrier function.