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Chinese Journal of Operative Procedures of General Surgery(Electronic Edition) ›› 2019, Vol. 13 ›› Issue (04): 430-432. doi: 10.3877/cma.j.issn.1674-3946.2019.04.035

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Recent Advances in protein phase separation

Song Liu1, Meng Wang1, Wenxian Guan1,()   

  1. 1. Department of General Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
  • Received:2018-10-29 Online:2019-08-26 Published:2019-08-26
  • Contact: Wenxian Guan
  • About author:
    Corresponding author: Guan Wenxian, Email:
  • Supported by:
    National Natural Science Foundation of China(81602103); Natural Science Foundation of Jiangsu Province(BK20160114); Distinguished Young Scholar Project of Medical Science and Technology Development Foundation of Nanjing Department of Health(JQX17005); Key Project of Medical Science and Technology Development Foundation of Nanjing Department of Health(YKK16114); Medical Research Program of Jiangsu Provincial Commission of Health and Family Planning(Q2017007); Wu Jieping Medical Foundation(320.2710.1817)

Abstract:

Phase separation is recently discovered as an efficient way of aggregation among homogenous molecules. Protein phase separation is widely existed in biology, and serves as a responsive and protective pattern in various (patho-)physiological processes. Dysfunction of phase separation leads to pathological aggregation, sedimentation and degeneration of proteins, and associates to metabolic and immunological diseases as well as tumors. This review is dedicated to summarize recent advances in the concept, clinical significance and methodology of phase separation, and raise key issues to be elucidated in the future.

Key words: Egg white, Phase transition, Fluorescence recovery after photobleaching, Phase separation

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