Abstract:
Objective To investigate the relationship between the liver fibrosis indexes and liver fat content quantitatively detected by in-phase opposed-phase T1WI sequences in patients with nonalcoholic fatty liver disease (NAFLD).
Methods 120 patients with NAFLD from June to August 2017 were selected. According to the NAFLD fibrosis score (NFS), the patients were divided into NFS<-1.455 subgroup (n=35, group A), -1.455≤NFS≤0.676 subgroup (n=41, group B) and NFS>0.676 subgroup (n=44, group C). A total of 50 healthy subjects with matching age, gender and region were selected as the control group. Serum CK18 and YKL40 levels were detected by ELISA, and liver fat content was detected by in-phase opposed-phase T1WI sequences. SPSS 19.0 statistical software was used for data analysis. Liver fibrosis indexes and liver fat relative content were showed as(±s), compared with independent t test. Multiple date sets were compared with Variance and Spearman correlation analysis, P<0.05 indicated the difference was statistically significant.
Results The values of CK18, YKL40, APRI and GPRI were increased significantly in C group patients, and negative correlation was found (r=-0.850, -0.584, -0.784 and -0.684, P<0.05). The relevance of values of CK18, YKL40, APRI and GPRI and liver fat content in group A and B was not found(P>0.05).
Conclusion Liver fibrosis trend was found in nonalcoholic steatohepatitis patients, and the liver fat content is closely related to the progression of liver fibrosis.
Key words:
Fatty liver,
Hepatitis,
Liver cirrhosis,
In-phase opposed-phase T1WI sequences
Likun Fu, Lina Sheng, Chunyan Zou, Jinglong Li, Changshun Xie, Yuemin Nan, Li Li. Correlation between serum fibrosis markers and intrahepatic fat content in patients with nonalcoholic fatty liver disease[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2019, 13(04): 385-387.