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中华普外科手术学杂志(电子版) ›› 2026, Vol. 20 ›› Issue (05) : 427 -431. doi: 10.3877/cma.j.issn.1674-3946.2026.05.006

论著

胃上部癌与胃下部癌淋巴结转移特征差异及预后相关性研究
王吉伟, 许治坤, 谢志远, 龚龙波†()   
  1. 221009 江苏徐州,徐州市中心医院胃肠外科
  • 收稿日期:2026-03-26 出版日期:2026-10-26
  • 通信作者: 龚龙波

A Study on the differences in lymph node metastasis characteristics and prognostic correlation between upper and lower gastric cancer

Jiwei Wang, Zhikun Xu, Zhiyuan Xie, Longbo Gong†()   

  1. Department of Gastrointestinal Surgery, Xuzhou Central Hospital, Xuzhou Jiangsu Province 221009, China
  • Received:2026-03-26 Published:2026-10-26
  • Corresponding author: Longbo Gong
  • Supported by:
    Jiangsu Province's Key Medical Discipline of the 14th Five-Year Plan(ZDXK202237)
引用本文:

王吉伟, 许治坤, 谢志远, 龚龙波. 胃上部癌与胃下部癌淋巴结转移特征差异及预后相关性研究[J/OL]. 中华普外科手术学杂志(电子版), 2026, 20(05): 427-431.

Jiwei Wang, Zhikun Xu, Zhiyuan Xie, Longbo Gong. A Study on the differences in lymph node metastasis characteristics and prognostic correlation between upper and lower gastric cancer[J/OL]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2026, 20(05): 427-431.

目的

探讨胃上部癌与胃下部癌的淋巴结转移分布特点、危险因素及预后差异。

方法

回顾性分析2018年1月至2020年1月1 318例胃腺癌行根治性胃切除术患者临床病例资料,按肿瘤部位分为胃上部癌组(n=612)与胃下部癌组(n=706)。采用SPSS26.0统计软件及R4.2.2软件分析数据。比较两组淋巴结转移特征,采用Logistic回归和Cox回归分析危险因素及预后影响因素。

结果

胃上部癌淋巴结转移率高于胃下部癌(35.3% vs 28.3%,P=0.009),转移淋巴结数目更多[(3.9±3.2) vs (3.0±2.8),P<0.001]。胃上部癌主要转移至第1、2、3、7组淋巴结,胃下部癌主要转移至第3、6、7、4组。肿瘤长径≥4 cm、低分化、pT3~4期、脉管浸润及神经浸润为淋巴结转移独立危险因素(均P<0.05)。胃上部癌3年生存率低于胃下部癌(88.7% vs 96.0%,P<0.001);年龄≥60岁、胃上部肿瘤、低分化、pTNM Ⅲ期、脉管浸润阳性及未接受辅助化疗是预后独立危险因素(均P<0.05)。

结论

胃上部癌与胃下部癌淋巴结转移模式及预后方面存在显著差异。肿瘤部位、病理特征及淋巴结转移状态对治疗策略制定具有重要指导意义。

Objective

To explore the characteristics of lymph node metastasis distribution, risk factors, and prognostic differences between upper and lower gastric cancers.

Methods

A retrospective analysis was conducted on the clinical case data of 1 318 patients with gastric adenocarcinoma who underwent radical gastrectomy from January 2018 to January 2020. The patients were divided into the upper gastric cancer group (n=612) and the lower gastric cancer group (n=706) based on the tumor location. SPSS 26.0 statistical software and R 4.2.2 software were used to analyze the data. The characteristics of lymph node metastasis in the two groups were compared. Logistic regression and Cox regression were used to analyze the risk factors and prognostic influencing factors.

Results

The lymph node metastasis rate of upper gastric cancer was higher than that of lower gastric cancer (35.3% vs 28.3%, P=0.009), and the number of metastatic lymph nodes was greater (3.9±3.2 vs 3.0±2.8, P<0.001). The upper gastric cancer mainly metastasized to the 1st, 2nd, 3rd, and 7th groups of lymph nodes, while the lower gastric cancer mainly metastasized to the 3rd, 6th, 7th, and 4th groups. Tumor length ≥ 4 cm, low differentiation, pT3-4 stage, vascular invasion, and nerve invasion were independent risk factors for lymph node metastasis (all P<0.05). The 3-year survival rate of upper gastric cancer was lower than that of lower gastric cancer (88.7% vs 96.0%, P<0.001); age ≥ 60 years, upper gastric tumor, low differentiation, pTNM stage Ⅲ, positive vascular invasion, and no receiving adjuvant chemotherapy were independent prognostic factors (all P<0.05).

Conclusion

There are significant differences in the lymph node metastasis patterns and prognosis between upper and lower gastric cancers.

表1 胃上部癌和胃下部癌两组患者基线资料及临床特征比较
表2 胃上部癌和胃下部癌两组患者淋巴结转移特征比较
表3 胃上部癌与胃下部癌两组患者淋巴结转移分布模式[例(%)]
表4 胃癌患者淋巴结转移与临床特征的关系
表5 胃癌患者预后的多因素Cox回归分析
图1 不同临床病理特征胃癌患者Kaplan-Meier生存曲线分析 A为年龄分组生存曲线;B为肿瘤位置分组生存曲线;C为病理分化程度分组生存曲线;D为浸润深度(pT分期)分组生存曲线;E为淋巴结转移(pN分期)生存曲线;F为pTNM分期分组生存曲线;G为脉管浸润分组生存曲线;H为神经浸润分组生存曲线;I为辅助化疗分组生存曲线 注:pT为病理T分期;pTNM为病理TNM分期
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