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中华普外科手术学杂志(电子版) ›› 2024, Vol. 18 ›› Issue (01) : 111 -114. doi: 10.3877/cma.j.issn.1674-3946.2024.01.029

综述

microRNA在三阴性乳腺癌进展中发挥的作用
马伟强, 马斌林(), 吴中语, 张莹   
  1. 830011 乌鲁木齐,新疆医科大学附属肿瘤医院乳腺甲状腺外科,新疆乳腺甲状腺肿瘤临床医学研究中心
  • 收稿日期:2023-08-09 出版日期:2024-02-26
  • 通信作者: 马斌林

The role of microRNA in the progression of triple-negative breast cancer

Weiqiang Ma, Binlin Ma(), Zhongyu Wu, Ying Zhang   

  1. Breast and Thyroid Surgery Department, Cancer Hospital Affiliated to Xinjiang Medical University, The Clinical Medical Research Center of Breast and Thyroid Tumor in Xinjiang,Urumqi 830011,China
  • Received:2023-08-09 Published:2024-02-26
  • Corresponding author: Binlin Ma
引用本文:

马伟强, 马斌林, 吴中语, 张莹. microRNA在三阴性乳腺癌进展中发挥的作用[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 111-114.

Weiqiang Ma, Binlin Ma, Zhongyu Wu, Ying Zhang. The role of microRNA in the progression of triple-negative breast cancer[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 111-114.

本研究旨在探讨microRNA(miRNA)在三阴性乳腺癌(TNBC)中的作用。重点介绍了TNBC的背景和临床特征,以及miRNA的基本概念和调控机制。详细描述了TNBC的分子特征,包括基因表达谱的差异和信号通路的异常激活,以及microRNA在TNBC中的作用。进一步讨论了microRNA在TNBC进展中的作用,包括其表达谱、作为TNBC预后标志物的潜力、以及作为TNBC治疗靶点的前景。评述了microRNA的检测和分析方法,以及基于高通量测序的研究策略。总结了对microRNA在TNBC进展中作用的认识,并指出了未来研究的重点和挑战,包括发现和验证新的miRNA靶标、确定miRNA调控网络的机制、以及开发针对microRNA的治疗策略。

The purpose of this study was to investigate the role of microRNA (miRNA) in triple negative breast cancer (TNBC). This paper focuses on the background and clinical features of TNBC, as well as the basic concepts and regulatory mechanisms of mirnas. The molecular characteristics of TNBC were described in detail, including differences in gene expression profiles and abnormal activation of signaling pathways, as well as the role of microRNA in TNBC. The role of microRNA in the progression of TNBC was further discussed, including its expression profile, potential as a prognostic marker for TNBC, and prospect as a therapeutic target for TNBC. The detection and analysis methods of microRNA and the research strategies based on high-throughput sequencing were reviewed. This review summarizes the understanding of the role of micrornas in the progression of TNBC, and identifies priorities and challenges for future research, including the discovery and validation of new miRNA targets, the identification of mechanisms of miRNA regulatory networks, and the development of therapeutic strategies targeting micrornas.

[1]
Yin LDuan JJBian XW,et al. Triple-negative breast cancer molecular subtyping and treatment progress[J]. Breast Cancer Res, 2020, 22(1): 61.
[2]
So JYOhm JLipkowitz S,et al. Triple negative breast cancer(TNBC): Non-genetic tumor heterogeneity and immune microenvironment: Emerging treatment options[J]. Pharmacol Ther, 2022, 237: 108253.
[3]
Zagami PCarey LA. Triple negative breast cancer: Pitfalls and progress[J]. npj Breast Cancer, 2022, 8(1): 95.
[4]
Johansson ALVTrewin CBHjerkind KV,et al. Breast cancer-specific survival by clinical subtype after 7 years follow-up of young and elderly women in a nationwide cohort[J]. Int J Cancer, 2019, 144(6): 1251–1261.
[5]
Bardia AHurvitz SATolaney SM,et al. Sacituzumab govitecan in metastatic triple-negative breast cancer[J]. New England Journal of Medicine, 2021, 384(16): 1529–1541.
[6]
Cortes JRugo HSCescon DW,et al. Pembrolizumab plus chemotherapy in advanced triple-negative breast cancer[J]. New England Journal of Medicine, 2022, 387(3): 217–26.
[7]
贾闵羽.雄激素受体与三阴性乳腺癌相关研究现状[J].中国医学科学院学报, 2023, 45(02): 303–310.
[8]
O'brien JHayder HZayed Y,et al. Overview of MicroRNA Biogenesis,Mechanisms of Actions,and Circulation[J]. Front Endocrinol(Lausanne), 2018, 9: 402.
[9]
Piasecka DBraun MKordek R,et al. MicroRNAs in regulation of triple-negative breast cancer progression[J]. J Cancer Res Clin Oncol, 2018, 144(8): 1401–1411.
[10]
Chen QLiu YGao Y,et al. A comprehensive genomic and transcriptomic dataset of triple-negative breast cancers[J]. Scientific Data, 2022, 9(1): 587.
[11]
Sabit HCevik ETombuloglu H,et al. Triple negative breast cancer in the era of miRNA[J]. Crit Rev Oncol Hematol, 2021, 157: 103196.
[12]
Xu JWu KJJia QJ,et al. Roles of miRNA and lncRNA in triple-negative breast cancer[J]. J Zhejiang Univ Sci B, 2020, 21(9): 673–89.
[13]
Panella RCotton CAMaymi VA,et al. Targeting of microRNA-22 Suppresses Tumor Spread in a Mouse Model of Triple-Negative Breast Cancer[J]. Biomedicines, 2023, 11(5): 1470.
[14]
Kahraman MRöske ALaufer T,et al. MicroRNA in diagnosis and therapy monitoring of early-stage triple-negative breast cancer[J]. Sci Rep, 2018, 8(1): 11584.
[15]
Abdel-Sater FNajar MFayyad-Kazan H. Triple negative breast cancer: microRNA expression profile and novel discriminators according to BRCA1 status[J]. J Cell Physiol, 2020, 235(6): 5204–5212.
[16]
Pollard JBurns PAHughes TA,et al. Differential Expression of MicroRNAs in Breast Cancers from Four Different Ethnicities[J]. Pathobiology, 2018, 85(4): 220–6.
[17]
Sharifi ZTalkhabi MTaleahmad S. Identification of potential microRNA diagnostic panels and uncovering regulatory mechanisms in breast cancer pathogenesis[J]. Scientific Reports, 2022, 12(1): 20135.
[18]
Turkistani SSugita BMFadda P,et al. A panel of miRNAs as prognostic markers for African-American patients with triple negative breast cancer[J]. BMC Cancer, 2021, 21(1): 861.
[19]
Hironaka-Mitsuhashi AMatsuzaki JTakahashi RU,et al. A tissue microRNA signature that predicts the prognosis of breast cancer in young women[J]. PLoS One, 2017, 12(11): e0187638.
[20]
Qattan A. Novel miRNA Targets and Therapies in the Triple-Negative Breast Cancer Microenvironment: An Emerging Hope for a Challenging Disease[J]. Int J Mol Sci, 2020, 21(23): 8905.
[21]
Grimaldi AMSalvatore MIncoronato M. miRNA-Based Therapeutics in Breast Cancer: A Systematic Review[J]. Front Oncol, 2021, 11: 668464.
[22]
Cheng YDong LZhang J,et al. Recent advances in microRNA detection[J]. Analyst, 2018, 143(8): 1758–1774.
[23]
Dave VPNgo TAPernestig AK,et al. MicroRNA amplification and detection technologies: opportunities and challenges for point of care diagnostics[J]. Lab Invest, 2019, 99(4): 452–469.
[24]
Loudig OLiu CRohan T,et al. Retrospective MicroRNA Sequencing: Complementary DNA Library Preparation Protocol Using Formalin-fixed Paraffin-embedded RNA Specimens. J Vis Exp, 2018, 5:(135): 57471.
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