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中华普外科手术学杂志(电子版) ›› 2024, Vol. 18 ›› Issue (01) : 100 -103. doi: 10.3877/cma.j.issn.1674-3946.2024.01.026

综述

减重术后胆囊结石形成机制的新进展
纪凯伦, 郝少龙, 孙海涛, 韩威()   
  1. 101149 北京,首都医科大学附属北京潞河医院普外科
    101149 北京,首都医科大学附属北京潞河医院普外科;101149 北京,首都医科大学附属北京潞河医院中心实验室
  • 收稿日期:2023-08-28 出版日期:2024-02-26
  • 通信作者: 韩威

New progress of gallstone formation mechanism after weight loss

Kailun Ji, Shaolong Hao, Haitao Sun, Wei Han()   

  1. Department of General Surgery, The Affiliated Luhe Hospital of Capital Medical University, Beijing 101149, China
    Department of General Surgery, The Affiliated Luhe Hospital of Capital Medical University, Beijing 101149, China;Central Lab, The Affiliated Luhe Hospital of Capital Medical University, Beijing 101149, China
  • Received:2023-08-28 Published:2024-02-26
  • Corresponding author: Wei Han
引用本文:

纪凯伦, 郝少龙, 孙海涛, 韩威. 减重术后胆囊结石形成机制的新进展[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 100-103.

Kailun Ji, Shaolong Hao, Haitao Sun, Wei Han. New progress of gallstone formation mechanism after weight loss[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 100-103.

肥胖影响人的呼吸、循环、内分泌以及生殖等多个系统,与糖尿病、高血压病、高脂血症等疾病关联密切,为解决肥胖的困扰,改善生活习惯、服用抗肥胖药物和行减重手术治疗是最常见的三种减重方式。其中,减重手术可以被认为是解决肥胖及其肥胖相关合并症的有效治疗方法。目前常用的减重手术类型包括腹腔镜可调节胃束带术、袖状胃切除术、胃大弯折叠术、胃旁路术等。随着减重手术的发展,减重术后的远期并发症也逐渐显露,减重术后胆囊结石作为减重手术常见的并发症之一,因可进一步诱发急性胆囊炎、胆管炎及胆源性胰腺炎的发生,已经引起学者们的广泛重视。本文通过检索相关文献,总结和分析了既往国内外学者在减重术后胆囊结石形成中的研究现况和存在问题,旨在为进一步探究减重术后胆囊结石形成的分子机制和寻找针对性防治措施提供参考。

Obesity affects people's respiratory, circulation, endocrine, reproductive and other systems, and is closely related to diabetes, hypertension, hyperlipidemia and other diseases. In order to solve the problem of obesity, improving living habits, taking anti-obesity drugs and weight loss surgery are the three most common ways. Among them, bariatric surgery can be considered an effective treatment to address obesity and its obesity-related comorbidities. At present, the commonly used types of weight loss surgery include laparoscopic adjustable gastric banding, sleeve gastrectomy, large gastric bending and folding, and gastric bypass. With the development of bariatric surgery, long-term complications after bariatric surgery have gradually emerged. As one of the common complications of bariatric surgery, gallstone after bariatric surgery has attracted extensive attention from scholars because it can further induce acute cholecystitis, cholangitis and biliary pancreatitis. By searching relevant literature, this paper summarizes and analyzes the current research status and existing problems of domestic and foreign scholars on the formation of gallstones after weight loss, aiming to provide reference for further exploring the molecular mechanism of the formation of gallstones after weight loss and searching for targeted prevention and treatment measures.

[3]
韩莹,齐向秀,刘丽娜. Roux-en-Y胃旁路术与袖状胃切除术治疗反复肥胖型急性高脂血症性胰腺炎的临床比较[J/CD].中华普外科手术学杂志(电子版), 2021, 15(03): 347–350.
[4]
买买提·依斯热依力,阿巴伯克力·乌斯曼,艾克拜尔·艾力等.腹腔镜袖状胃切除术治疗肥胖合并2型糖尿病的临床研究[J/CD].中华普外科手术学杂志(电子版), 2021, 15(05): 497–500.
[5]
Liakopoulos VFranzén SSvensson AM,et al. Pros and cons of gastric bypass surgery in individuals with obesity and type 2 diabetes: nationwide,matched,observational cohort study[J]. BMJ Open, 2019, 9(1): e023882.
[6]
Sneineh MAHarel LElnasasra A,et al. Increased incidence of symptomatic cholelithiasis after bariatric roux-en-y gastric bypass and previous bariatric surgery: a single center experience[J]. Obesity Surgery, 2020, 30(3): 846–850.
[7]
Talha AAbdelbaki TFarouk A,et al. Cholelithiasis after bariatric surgery,incidence,and prophylaxis: randomized controlled trial[J]. Surgical Endoscopy, 2019, 34(12): 5331–5337.
[8]
Yuan SGill DGiovannucci EL,et al. Obesity,type 2 diabetes,lifestyle factors,and risk of gallstone disease: a mendelian randomization investigation[J]. Clinical Gastroenterology and Hepatology, 2022, 20(3): e529–e537.
[9]
Altieri MSYang JNie L,et al. Incidence of cholecystectomy after bariatric surgery[J]. Surgery for Obesity and Related Diseases, 2018, 14(7): 992–996.
[10]
Alsaif FAlabdullatif FAldegaither M,et al. Incidence of symptomatic cholelithiasis after laparoscopic sleeve gastrectomy and its association with rapid weight loss[J]. Saudi Journal of Gastroenterology, 2020, 26(2): 94–98.
[11]
Verhoeff KMocanu VDang J,et al. Characterization and risk factors for early biliary complications following elective bariatric surgery: an mbsaqip analysis[J]. Obesity Surgery, 2022, 32(4): 1170–1177.
[12]
Tsirline VBKeilani ZMEl Djouzi S,et al. How frequently and when do patients undergo cholecystectomy after bariatric surgery?[J]. Surgery for Obesity and Related Diseases, 2014, 10(2): 313–321.
[13]
Guzmán HMSepúlveda MRosso N,et al. Incidence and risk factors for cholelithiasis after bariatric surgery[J]. Obesity Surgery, 2019, 29(7): 2110–2114.
[14]
Alimoğulları MBuluş H. Predictive factors of gallstone formation after sleeve gastrectomy: a multivariate analysis of risk factors[J]. Surgery Today, 2020, 50(9): 1002–1007.
[15]
Hashimoto KNagao YNambara S,et al. Association between anti-helicobacter pylori antibody seropositive and de novo gallstone formation after laparoscopic sleeve gastrectomy for japanese patients with severe obesity[J]. Obesity Surgery, 2022, 32(10): 3404–3409.
[16]
Di Ciaula AWang D Q-HPortincasa P. An update on the pathogenesis of cholesterol gallstone disease[J]. Current Opinion in Gastroenterology, 2018, 34(2): 71–80.
[17]
Krawczyk MLütjohann DSchirin-Sokhan R,et al. Phytosterol and cholesterol precursor levels indicate increased cholesterol excretion and biosynthesis in gallstone disease[J]. Hepatology, 2012, 55(5): 1507–1517.
[18]
Benetti ADel Puppo MCrosignani A,et al. Cholesterol metabolism after bariatric surgery in grade 3 obesity: differences between malabsorptive and restrictive procedures[J]. Diabetes Care, 2012, 36(6): 1443–1447.
[19]
Ji YLee HKaura S,et al. Effect of bariatric surgery on metabolic diseases and underlying mechanisms[J]. Biomolecules, 2021, 11(11): 1582.
[20]
Akalestou EMiras ADRutter GA,et al. Mechanisms of weight loss after obesity surgery[J]. Endocrine Reviews, 2021, 43(1): 19–34.
[21]
Yoo KSChoi HSJun DW,et al. MUC expression in gallbladder epithelial tissues in cholesterol-associated gallbladder disease[J]. Gut and Liver, 2016, 10(5): 851–858.
[1]
Pan XFWang LPan A. Epidemiology and determinants of obesity in china[J]. Lancet Diabetes Endocrinol, 2021, 9(6): 373–392.
[2]
Lin XLi H. Obesity: epidemiology,pathophysiology,and therapeutics[J]. Frontiers in Endocrinology, 2021, 12: 706978.
[22]
Wang HHAfdhal NHGendler SJ,et al. Evidence that gallbladder epithelial mucin enhances cholesterol cholelithogenesis in muc1 transgenic mice[J]. Gastroenterology, 2006, 131(1): 210–222.
[23]
Gustafsson UBenthin LGranström L,et al. Changes in gallbladder bile composition and crystal detection time in morbidly obese subjects after bariatric surgery[J]. Hepatology, 2005, 41(6): 1322–1328.
[24]
Lavoie BNausch BZane EA,et al. Disruption of gallbladder smooth muscle function is an early feature in the development of cholesterol gallstone disease[J]. Neurogastroenterology &Motility, 2012, 24(7): e313–e324.
[25]
Al-Jiffry BOShaffer EASaccone GT,et al. Changes in gallbladder motility and gallstone formation following laparoscopic gastric banding for morbid obesity[J]. Canadian Journal of Gastroenterology, 2003, 17(3): 169–174.
[26]
Gether IMNexøe-Larsen CKnop FK. New avenues in the regulation of gallbladder motility—implications for the use of glucagon-like peptide–derived drugs[J]. The Journal of Clinical Endocrinology &Metabolism, 2018, 104(7): 2463–2472.
[27]
Hu HShao WLiu Q,et al. Gut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion[J]. Nature Communications, 2022, 13(1): 252.
[28]
Chaudhari SNLuo JNHarris DA,et al. A microbial metabolite remodels the gut-liver axis following bariatric surgery[J]. Cell Host &Microbe, 2021, 29(3): 408–424.e7.
[29]
Wang QJiao LHe C,et al. Alteration of gut microbiota in association with cholesterol gallstone formation in mice[J]. BMC Gastroenterology, 2017, 17(1): 74.
[30]
Jahansouz CStaley CBernlohr D A,et al. Sleeve gastrectomy drives persistent shifts in the gut microbiome[J]. Surgery for Obesity and Related Diseases, 2017, 13(6): 916–924.
[31]
Ribeiro-Parenti LJarry ACCavin JB,et al. Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells[J]. Nature Communications, 2021, 12(1): 110.
[32]
Zhang ZDu ZLiu Q,et al. Glucagon-like peptide 1 analogue prevents cholesterol gallstone formation by modulating intestinal farnesoid x receptor activity[J]. Metabolism, 2021, 118: 154728.
[33]
Albaugh VLBanan BAntoun J,et al. Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery[J].Gastroenterology, 2019, 156(4): 1041–1051.e4.
[34]
Cunningham RMJones KTKuhn JE,et al. Asymptomatic cholelithiasis and bariatric surgery: a comprehensive long-term analysis of the risks of biliary disease in patients undergoing primary roux-en-y gastric bypass[J]. Obesity Surgery, 2020, 31(3): 1249–1255.
[35]
Şen OTürkçapar AG. Risk of asymptomatic gallstones becoming symptomatic after laparoscopic sleeve gastrectomy[J]. The American Surgeon, 2023, 89(1): 69–71.
[36]
Della Penna ALange JHilbert J,et al. Ursodeoxycholic acid for 6 months after bariatric surgery is impacting gallstone associated morbidity in patients with preoperative asymptomatic gallstones[J]. Obesity Surgery, 2019, 29(4): 1216–1221.
[37]
Haal SGuman MSSDe Brauw LM,et al. Cost-effectiveness of ursodeoxycholic acid in preventing new-onset symptomatic gallstone disease after Roux-en-Y gastric bypass surgery[J]. British Journal of Surgery, 2022, 109(11): 1116–1123.
[38]
Cao CShao YKYao QY. Role and change of the gut microbiota after bariatric surgery[J]. Chinese journal of gastrointestinal surgery, 2022, 25(7): 648–653.
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