研究乙型肝炎病毒（HBV）相关肝硬化合并急性上消化道出血的危险因素。

回顾性分析2016年7月至2021年7月期间收治的258例HBV相关肝硬化患者临床资料，按照是否合并急性上消化道出血分为出血组（n=142）和未出血组（n=116）。数据采用统计学软件SPSS 22.0进行统计分析，正态分布计量资料用（）表示，行独立样本t检验；计数资料以[例(%)]表示，采用χ²检验；单因素和多因素分析采用Logistic回归模型。 P<0.05为差异有统计学意义。

单因素分析显示，肝功能分级、凝血酶原时间、胃左静脉内径及血红蛋白为HBV相关肝硬化合并急性上消化道出血的危险因素（P<0.05）；多因素分析表明，肝功能分级（OR=1.29，95%CI: 1.06-1.90）、凝血酶原时间（OR=1.68，95%CI: 1.14-2.28）及胃左静脉内径（OR=2.08，95%CI: 1.27-2.97）为影响HBV相关肝硬化并急性上消化道出血的独立危险因素。

HBV相关肝硬化合并急性上消化道出血的危险因素中肝功能分级、凝血酶原时间及胃左静脉内径为其独立危险因素。

To study the risk factors of acute upper gastrointestinal bleeding in hepatitis B virus (HBV) related cirrhosis.

A retrospective analysis was conducted on 258 patients with HBV related cirrhosis admitted between July 2016 and July 2021. They were divided into a bleeding group of 142 patients (bleeding group) and a non bleeding group of 116 patients (non bleeding group) based on whether they were complicated with acute upper gastrointestinal bleeding. The statistical software SPSS 22.0 was used for statistical analysis. The measurement data of normal distribution () were tested by t test, and the counting data were expressed in rate (%) by χ2 test; Logistic regression models were used for single factor and multivariate analysis. The difference was statistically significant with P<0.05.

Univariate analysis showed that liver function grading, prothrombin time, left gastric vein flow, and hemoglobin were risk factors for HBV related cirrhosis with acute upper gastrointestinal bleeding (P<0.05); Multivariate analysis showed that Grade C liver function (OR=1.29, 95%CI：1.06-1.90), prothrombin time >16s (OR=1.68, 95%CI：1.14-2.28) and internal channel of left gastric vein (OR=2.08, 95%CI：1.27-2.97) were independent risk factors for HBV related cirrhosis with acute upper gastrointestinal bleeding.

Among the risk factors for HBV related cirrhosis combined with acute upper gastrointestinal bleeding, liver function grading, prothrombin time, and left gastric vein internal circulation are independent risk factors.