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中华普外科手术学杂志(电子版) ›› 2026, Vol. 20 ›› Issue (04) : 390 -393. doi: 10.3877/cma.j.issn.1674-3946.2026.04.020

综述

肝门部胆管癌胆道穿刺引流后胆汁回输的临床价值与研究进展
李晶晶, 闫伟娜, 贾波, 刘灿, 徐竟益()   
  1. 102218 北京,清华大学北京清华长庚医院肝胆胰外科
  • 收稿日期:2025-11-19 出版日期:2026-08-26
  • 通信作者: 徐竟益

Clinical value and research progress of bile reinfusion after percutaneous transhepatic biliary drainage in hilar cholangiocarcinoma

Jingjing Li, Weina Yan, Bo Jia, Can Liu, Jingyi Xu()   

  1. Department of Hepatobiliary Pancreatic Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China
  • Received:2025-11-19 Published:2026-08-26
  • Corresponding author: Jingyi Xu
引用本文:

李晶晶, 闫伟娜, 贾波, 刘灿, 徐竟益. 肝门部胆管癌胆道穿刺引流后胆汁回输的临床价值与研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2026, 20(04): 390-393.

Jingjing Li, Weina Yan, Bo Jia, Can Liu, Jingyi Xu. Clinical value and research progress of bile reinfusion after percutaneous transhepatic biliary drainage in hilar cholangiocarcinoma[J/OL]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2026, 20(04): 390-393.

肝门部胆管癌(HCCA)所致的梗阻性黄疸常需术前或姑息性胆道减压。经皮经肝胆道引流(PTBD)与外引流是目前最常用的手段之一,但长期大量胆汁体外丢失可导致水-电解质紊乱、脂肪泻及肠道屏障受损。胆汁回输(BR)技术通过“体外引流-体内回输”闭环,理论上可恢复肠肝循环、保护肠道微生态并改善营养状况。本文系统回顾近年来公开发表的临床研究、实验与Meta分析,对HCCA患者PTBD后BR的适应证、技术路径、疗效证据及潜在风险进行综述,为临床实践和未来研究提供参考。

Obstructive jaundice induced by hilar cholangiocarcinoma (HCCA) often requires preoperative or palliative biliary decompression. Percutaneous transhepatic biliary drainage (PTBD) with external drainage is one of the most widely adopted modalities at present. Nevertheless, long-term massive extrahepatic bile loss may trigger water-electrolyte disorders, steatorrhea and impairment of the intestinal barrier. The bile reinfusion (BR) technique forms a closed loop of "extracorporeal drainage and intracorporeal reinfusion", which can theoretically restore the enterohepatic circulation, preserve intestinal microecology and improve nutritional status. This paper systematically reviews published clinical trials, experimental studies and meta-analyses in recent years, and summarizes the indications, technical protocols, efficacy evidence and potential risks of BR after PTBD in patients with HCCA, so as to provide references for clinical practice and future research.

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