随着微创技术的进步和腹腔镜器械的发展，胰腺外科已经步入微创时代，其中腹腔镜胰十二指肠切除术发展迅速，已成为治疗胰头良恶性肿瘤的常规术式，受到广大外科医师的推崇。本文从术前评估、手术入路、吻合方式、复杂情况处理以及质量控制方面，对腹腔镜胰十二指肠切除术的要点与原则进行介绍，以期进一步增强我国腹腔镜胰十二指肠切除术的规范。

With the progress of minimally invasive technology and the development of laparoscopic instruments, pancreatic surgery has entered a minimally invasive era. Laparoscopic pancreaticoduodenectomy has developed rapidly and become a routine operation for the treatment of benign and malignant tumors of the head of the pancreas, which is highly respected by surgeons. In this paper, the key points and principles of laparoscopic pancreaticoduodenectomy were introduced from the aspects of preoperative evaluation, surgical approach, anastomosis, complex situation management and quality control, so as to further improve the standard of laparoscopic pancreaticoduodenectomy in China.