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中华普外科手术学杂志(电子版) ›› 2023, Vol. 17 ›› Issue (01) : 95 -97. doi: 10.3877/cma.j.issn.1674-3946.2023.01.024

综述

围手术期炎症对胃肠肿瘤预后影响的研究进展
徐芸若1, 王国斌2, 王征3,(), 王琳1,()   
  1. 1. 430022 武汉,华中科技大学同济医学院附属协和医院检验科;430022 武汉,华中科技大学同济医学院附属协和医院组织工程与再生医学研究中心
    2. 430022 武汉,华中科技大学同济医学院附属协和医院胃肠外科
    3. 430022 武汉,华中科技大学同济医学院附属协和医院组织工程与再生医学研究中心;430022 武汉,华中科技大学同济医学院附属协和医院胃肠外科
  • 收稿日期:2022-03-05 出版日期:2023-02-26
  • 通信作者: 王征, 王琳

Advances on the effects of perioperative inflammation on the prognosis of gastrointestinal neoplasms

Yunruo Xu1, Guobin Wang2, Zheng Wang3,(), Lin Wang1,()   

  1. 1. Department of Clinical Laboratory,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei Province 430022,China;Research Center for Tissue Engineering and Regenerative Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei Province 430022,China
    2. Department of Gastrointestinal Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei Province 430022,China
    3. Research Center for Tissue Engineering and Regenerative Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei Province 430022,China;Department of Gastrointestinal Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei Province 430022,China
  • Received:2022-03-05 Published:2023-02-26
  • Corresponding author: Zheng Wang, Lin Wang
  • Supported by:
    National Natural Science Foundation of China(81974382)
引用本文:

徐芸若, 王国斌, 王征, 王琳. 围手术期炎症对胃肠肿瘤预后影响的研究进展[J]. 中华普外科手术学杂志(电子版), 2023, 17(01): 95-97.

Yunruo Xu, Guobin Wang, Zheng Wang, Lin Wang. Advances on the effects of perioperative inflammation on the prognosis of gastrointestinal neoplasms[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(01): 95-97.

胃肠肿瘤术后常发生复发和远处转移,严重影响患者预后,是外科亟待解决的重要问题。目前研究已揭示炎症与肿瘤发生发展的密切联系。炎症伴随着整个围手术期,包括术前肿瘤微环境相关炎症、创伤相关炎症及术后感染相关炎症,这些炎症可表现为促瘤和抑瘤的双重作用。促瘤炎症成为主导时,则可刺激肿瘤原位复发,降低总体生存率。因此有必要对围手术期相关炎症的倾向进行评估。本文综述了国内外基础及临床研究的相关最新进展,简要阐述了炎症作用机制及相应评价指标。

Postoperative recurrence and distant metastasis of gastrointestinal tumors often occur,which seriously affects the prognosis of patients and is an important problem to be solved urgently in surgery. Current studies have revealed the close relationship between inflammation and the occurrence and development of tumors. Inflammation is associated with the entire perioperative period,including preoperative tumor microenvironment-related inflammation,trauma-related inflammation,and postoperative infection-related inflammation. These inflammation can be both pro-tumor and anti-tumor. When pro-tumor inflammation becomes dominant,it can stimulate tumor recurrence in situ and reduce overall survival. Therefore,it is necessary to evaluate the tendency of perioperative inflammation. In this paper,the latest progress of basic and clinical research at home and abroad is reviewed,and the mechanism of inflammation and corresponding evaluation indexes are briefly described.

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