探讨细胞减灭术（CＲS）加腹腔热灌注化疗（HIPEC）在治疗腹膜假黏液瘤（PMP）中临床价值。

回顾性分析2017年3月至2018年3月50例腹膜假黏液瘤行CRS+HIPEC的患者病例资料并查阅国内外相关文献。

50例患者中，初诊20例，复发30例；行腹腔镜下CRS+HIPEC 7例，开腹下CRS+HIPEC 43例；低级别PMP 41例，高级别PMP 9例。术前肿瘤标志物升高33例，正常17例；联合2脏器切除18例，3脏器切除21例，4脏器以上切除27例，常见联合切除脏器依次为结肠、小肠、脾脏、胃、胆囊；术后出现胸腔积液11例、吻合口漏2例、肠梗阻7例、腹腔脓肿3例、腹腔出血1例、泌尿系瘘1例、切口感染4例、下肢静脉栓塞6例，死亡1例；出血量50~10000 ml，平均696 ml；手术时间4~15 h，平均7.8 h；住院时间5~21 d，平均12.4 d。术后随访时间1年，出现复发13例，死亡1例。

CRS+HIPEC作为PMP的标准诊疗技术，亟需临床推广，以改善目前国内PMP治疗现状。

To investigate the clinical value of cytoreductive surgery（CRS）combined with hyperthermic intraperitoneal chemotherapy（HIPEC）in the treatment of peritoneal pseudomyxoma（PMP）.

A retrospective analysis was given to the case history data of 50 patients diagnosed with PMP who received CRS+HIPEC in the period from March 2017 to March 2018. Relevant domestic and foreign literature was also consulted.

Among the 50 patients，20 were newly diagnosed and 30 had recurrence. 7 cases underwent laparoscopic CRS+HIPEC and 43 cases underwent open CRS+HIPEC. There were 41 cases of low-grade PMP and 9 cases of high-grade PMP. Preoperative tumor markers were elevated in 33 cases and normal in 17 cases. Combined resection of 2 organs was performed in 18 cases，3 organs in 21 cases，and more than 4 organs in 27 cases. The common combined resection organs were colon，small intestine，spleen，stomach，and gallbladder. There were 11 cases of pleural effusion，2 cases of anastomotic leakage，7 cases of intestinal obstruction，3 cases of abdominal abscess，1 case of abdominal hemorrhage，1 case of urinary fistula，4 cases of incision infection，6 cases of lower extremity venous embolism，and 1 case of death. The blood loss was 50~10000 ml（mean，696ml）. The operation time was 4~15 hours（mean，7.8 hours）. The mean hospital stay was 12.4 days（range，5~21 days）. During 1 year follow-up，13 cases had recurrence and 1 case died.

CRS+HIPEC，as a standard diagnosis and treatment technique for PMP，is in urgent need of clinical promotion to improve the current situation of PMP treatment in China.

CRS+HIPEC，as a standard diagnosis and treatment technique for PMP，is in urgent need of clinical promotion to improve the current status of PMP treatment in China.