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中华普外科手术学杂志(电子版) ›› 2026, Vol. 20 ›› Issue (05) : 495 -500. doi: 10.3877/cma.j.issn.1674-3946.2026.05.019

综述

肝细胞癌术后早期复发危险因素研究进展
王中尧, 李敬东†()   
  1. 637000 南充,川北医学院附属医院肝胆外一科,川北医学院肝胆胰肠疾病研究所
  • 收稿日期:2026-01-27 出版日期:2026-10-26
  • 通信作者: 李敬东

Research progress on risk factors for early recurrence after hepatocellular carcinoma surgery

Zhongyao Wang, Jingdong Li†()   

  1. The First Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong Sichuan Province 637000, China
  • Received:2026-01-27 Published:2026-10-26
  • Corresponding author: Jingdong Li
引用本文:

王中尧, 李敬东. 肝细胞癌术后早期复发危险因素研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2026, 20(05): 495-500.

Zhongyao Wang, Jingdong Li. Research progress on risk factors for early recurrence after hepatocellular carcinoma surgery[J/OL]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2026, 20(05): 495-500.

肝细胞癌根治术后早期复发(≤2年)是影响患者生存的主要挑战,严重影响预后。现围绕术后早期复发的危险因素展开综述,系统梳理了包括肿瘤分化程度、大小、数目、血管浸润、包膜完整性、肝硬化状态在内的肿瘤特征;切缘宽度、术中失血与输血、切除方式等手术相关因素;血清分子标志物以及肿瘤免疫微环境在预测早期复发中的作用。综合分析上述因素有助于识别高危患者,为优化手术策略、加强术后监测提供依据,对改善肝细胞癌患者整体预后具有重要意义。

Early recurrence (≤2years) after radical resection of hepatocellular carcinoma is a major challenge affecting patient survival and significantly impacts prognosis. This review focuses on the risk factors for early recurrence after surgery, systematically summarizing tumor characteristics such as tumor differentiation degree, size, number, vascular invasion, integrity of the capsule, and liver cirrhosis status; surgical-related factors including margin width, intraoperative blood loss and blood transfusion, and resection method; as well as the role of serum molecular markers and tumor immune microenvironment in predicting early recurrence. Comprehensive analysis of these factors is helpful in identifying high-risk patients, providing a basis for optimizing surgical strategies and strengthening postoperative monitoring, and is of great significance for improving the overall prognosis of patients with hepatocellular carcinoma.

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