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中华普外科手术学杂志(电子版) ›› 2023, Vol. 17 ›› Issue (03) : 332 -335. doi: 10.3877/cma.j.issn.1674-3946.2023.03.025

综述

林奇综合征的治疗现状及进展
汪必涛1, 王征2, 王国斌1,()   
  1. 1. 430022 武汉,华中科技大学同济医学院附属协和医院胃肠外科
    2. 430022 武汉,华中科技大学同济医学院附属协和医院胃肠外科;430022 武汉,华中科技大学同济医学院附属协和医院组织工程与再生医学研究中心
  • 收稿日期:2022-12-17 出版日期:2023-06-26
  • 通信作者: 王国斌

Treatment status and progress of Lynch syndrome

Bitao Wang1, Zheng Wang2, Guobin Wang1,()   

  1. 1. Department of Gastrointestinal Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei Province 430022,China
    2. Department of Gastrointestinal Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei Province 430022,China; Research Center for Tissue Engineering and Regenerative Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei Province 430022,China
  • Received:2022-12-17 Published:2023-06-26
  • Corresponding author: Guobin Wang
  • Supported by:
    National Natural Science Foundation of China(82173315, 82072743, 81974382); The Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College, Huazhong University of Science and Technology
引用本文:

汪必涛, 王征, 王国斌. 林奇综合征的治疗现状及进展[J]. 中华普外科手术学杂志(电子版), 2023, 17(03): 332-335.

Bitao Wang, Zheng Wang, Guobin Wang. Treatment status and progress of Lynch syndrome[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(03): 332-335.

林奇综合征(LS)是一种遗传性肿瘤综合征。由于LS患者易发生结直肠、妇科及上消化道等部位的肿瘤,且发病早、终生发病率高,因此确诊后选择恰当有效的治疗手段十分重要。目前,手术及化学治疗仍然是LS的主要治疗手段,然而这两种治疗手段的效果仍不理想。而随着免疫治疗的发展,肿瘤疫苗,尤其是移码肽疫苗已初露锋芒,有望转化应用。本文将重点从LS的治疗进展以及预防等方面展开综述。

Lynch syndrome(LS)is a hereditary tumor syndrome. Since LS patients are prone to colorectal,gynecological and upper digestive tract tumors with early onset and high lifetime incidence,it is very important to select appropriate and effective treatment methods after diagnosis. At present,surgery and chemotherapy are still the main treatments for LS,but the effects of these two treatments are still not ideal. With the development of immunotherapy,tumor vaccines,especially the frameshift peptide vaccine,have begun to emerge and are expected to be transformed and applied. This article will focus on the treatment progress and prevention of LS and other aspects of review.

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