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中华普外科手术学杂志(电子版) ›› 2026, Vol. 20 ›› Issue (06) : 606 -609. doi: 10.3877/cma.j.issn.1674-3946.2026.06.021

综述

胆囊切除术后综合征的临床诊疗进展
施健华, 张剑, 宋海兵, 顾颖浩†()   
  1. 226241 江苏 南通,启东市第二人民医院普外科
  • 收稿日期:2026-06-25 出版日期:2026-12-26
  • 通信作者: 顾颖浩

Clinical diagnosis and treatment progress of post-cholecystectomy syndrome

Jianhua Shi, Jian Zhang, Haibing Song, Yinghao Gu†()   

  1. Department of General Surgery, the Second People's Hospital of Qidong, Nantong Jiangsu Province 226241, China
  • Received:2026-06-25 Published:2026-12-26
  • Corresponding author: Yinghao Gu
引用本文:

施健华, 张剑, 宋海兵, 顾颖浩. 胆囊切除术后综合征的临床诊疗进展[J/OL]. 中华普外科手术学杂志(电子版), 2026, 20(06): 606-609.

Jianhua Shi, Jian Zhang, Haibing Song, Yinghao Gu. Clinical diagnosis and treatment progress of post-cholecystectomy syndrome[J/OL]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2026, 20(06): 606-609.

胆囊切除术后综合征(PCS)是胆囊切除手术后持续存在的消化道病症。由于病因复杂,诊断困难且治疗手段多样化,PCS一直是胆道外科领域内的临床难题。本文对PCS的多因素病因学进行综述,涵盖胆道因素、肝外因素及肠道菌群变化在发病机制中的最新进展;解析了内镜超声(EUS),SeHCAT扫描及Oddi括约肌测压等诊断技术的分层应用策略;归纳了饮食管控,药物疗法,内镜介入及中医药施治等多种策略;并评估SECURE试验、SUCCESS预测模型及PERFECT试验在术前患者筛选方面的应用潜力,强调精准挑选手术适应症对降低PCS发生风险的重要意义。

Post-cholecystectomy syndrome (PCS) is a persistent digestive disorder that persists after cholecystectomy surgery. Due to its complex etiology, difficult diagnosis, and diverse treatment options, PCS has long been a clinical challenge in the field of biliary surgery. This article reviews the multifactorial etiology of PCS, covering the latest progress in the pathogenesis of biliary factors, extrahepatic factors, and changes in the intestinal microbiota; analyzes the stratified application strategies of diagnostic techniques such as endoscopic ultrasound (EUS), SeHCAT scanning, and Oddi sphincter pressure measurement; summarizes various treatment strategies including dietary control, drug therapy, endoscopic intervention, and traditional Chinese medicine treatment; and assesses the application potential of the SECURE trial, the SUCCESS prediction model, and the PERFECT trial in preoperative patient screening, emphasizing the significance of precisely selecting surgical indications in reducing the risk of PCS occurrence.

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